2-Methyl-4-((1'R)-2',2',4'-trimethyl-3'-oxocyclohexyl)-2-butensaeure-ethylester

Base Information

Chemical Name:2-Methyl-4-((1'R)-2',2',4'-trimethyl-3'-oxocyclohexyl)-2-butensaeure-ethylester
CAS No.:108361-29-1
Molecular Formula:C₁₆H₂₆O₃
Molecular Weight:266.381
Hs Code.:

Synonyms:2-Methyl-4-((1'R)-2',2',4'-trimethyl-3'-oxocyclohexyl)-2-butensaeure-ethylester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Methyl-4-((1'R)-2',2',4'-trimethyl-3'-oxocyclohexyl)-2-butensaeure-ethylester

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Technology Process of 2-Methyl-4-((1'R)-2',2',4'-trimethyl-3'-oxocyclohexyl)-2-butensaeure-ethylester

There total 6 articles about 2-Methyl-4-((1'R)-2',2',4'-trimethyl-3'-oxocyclohexyl)-2-butensaeure-ethylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 61553-29-5
2-(diethoxyphosphoryl)propionic acid ethyl ester

: 108361-22-4
(3R)-3-oxo-2,2,4-trimethylcyclohexan-1-acetaldehyde

: 108361-29-1
2-Methyl-4-((1'R)-2',2',4'-trimethyl-3'-oxocyclohexyl)-2-butensaeure-ethylester

Guidance literature:: With sodium ethanolate; In ethanol; dichloromethane; at 0 ℃; for 0.5h;
DOI:10.1002/hlca.19860690315

Reference yield:

: 108361-18-8
(R)-2,2,4-trimethyl-3-cyclohexen-1-acetaldehyde

: 108361-29-1
2-Methyl-4-((1'R)-2',2',4'-trimethyl-3'-oxocyclohexyl)-2-butensaeure-ethylester

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / PPTS / benzene / 23 h / Heating

2: 1.) Me₂S*BH₃, 3.) 30percent H₂O₂, 3N NaOH / 1.) ether, 0 deg C, 15 min, 2.) RT, 4 h, 3.) reflux, 1 h

3: 82 percent / CrO₃, pyridine / CH₂Cl₂ / 0.25 h

4: 99 percent / H₂O / PPTS / acetone / 48 h / Heating

5: 78 percent / NaOEt / CH₂Cl₂; ethanol / 0.5 h / 0 °C

With pyridine; chromium(VI) oxide; sodium hydroxide; dimethylsulfide borane complex; water; dihydrogen peroxide; sodium ethanolate; pyridinium p-toluenesulfonate; pyridinium p-toluenesulfonate; In ethanol; dichloromethane; acetone; benzene;
DOI:10.1002/hlca.19860690315

Reference yield:

: 108361-17-7
(R)-2,2,4-trimethyl-3-cyclohexen-1-acetonitrile

: 108361-29-1
2-Methyl-4-((1'R)-2',2',4'-trimethyl-3'-oxocyclohexyl)-2-butensaeure-ethylester

Guidance literature:: Multi-step reaction with 6 steps

1: 93 percent / DIBAH / hexane / 1.) -60 deg C, 2.) RT, 1 h

2: 95 percent / PPTS / benzene / 23 h / Heating

3: 1.) Me₂S*BH₃, 3.) 30percent H₂O₂, 3N NaOH / 1.) ether, 0 deg C, 15 min, 2.) RT, 4 h, 3.) reflux, 1 h

4: 82 percent / CrO₃, pyridine / CH₂Cl₂ / 0.25 h

5: 99 percent / H₂O / PPTS / acetone / 48 h / Heating

6: 78 percent / NaOEt / CH₂Cl₂; ethanol / 0.5 h / 0 °C

With pyridine; chromium(VI) oxide; sodium hydroxide; dimethylsulfide borane complex; water; dihydrogen peroxide; sodium ethanolate; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; pyridinium p-toluenesulfonate; In ethanol; hexane; dichloromethane; acetone; benzene;
DOI:10.1002/hlca.19860690315