2,8-dibenzyl-6-methyl-2,3-dihydro-8H-pyrazino[1,2-a]pyrazine-1,4,7-trione

Base Information

Chemical Name:2,8-dibenzyl-6-methyl-2,3-dihydro-8H-pyrazino[1,2-a]pyrazine-1,4,7-trione
CAS No.:215534-68-2
Molecular Formula:C₂₂H₂₁N₃O₃
Molecular Weight:375.427
Hs Code.:

2,8-dibenzyl-6-methyl-2,3-dihydro-8<i>H</i>-pyrazino[1,2-<i>a</i>]pyrazine-1,4,7-trione

Synonyms:2,8-dibenzyl-6-methyl-2,3-dihydro-8H-pyrazino[1,2-a]pyrazine-1,4,7-trione

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Chemical Property of 2,8-dibenzyl-6-methyl-2,3-dihydro-8H-pyrazino[1,2-a]pyrazine-1,4,7-trione

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Technology Process of 2,8-dibenzyl-6-methyl-2,3-dihydro-8H-pyrazino[1,2-a]pyrazine-1,4,7-trione

There total 5 articles about 2,8-dibenzyl-6-methyl-2,3-dihydro-8H-pyrazino[1,2-a]pyrazine-1,4,7-trione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 261729-76-4
(benzyl-{3-[benzyl-(2-tert-butoxycarbonylamino-propionyl)-amino]-2-oxo-propionyl}-amino)-acetic acid ethyl ester

: 215534-68-2
2,8-dibenzyl-6-methyl-2,3-dihydro-8H-pyrazino[1,2-a]pyrazine-1,4,7-trione

Guidance literature:: With trifluoroacetic acid;
DOI:10.1021/ol990355r

Reference yield:

: 6436-90-4
ethyl 2-(benzylamino)acetate

: 215534-68-2
2,8-dibenzyl-6-methyl-2,3-dihydro-8H-pyrazino[1,2-a]pyrazine-1,4,7-trione

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / EDCI; HOBt

2: 100 percent / LiOH / H₂O; tetrahydrofuran

3: EDCI; DMAP / CH₂Cl₂

4: 41 percent / CH₂Cl₂ / -78 °C

5: 77 percent / TFA

With dmap; lithium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; 1: Acylation / 2: Hydrolysis / 3: Condensation / 4: ozonolysis / 4: Condensation / 5: Cyclization;
DOI:10.1021/ol990355r

Reference yield:

: 215534-63-7
N-[N-[(1,1-dimethylethoxy)carbonyl]-L-alanyl]-N-(phenylmethyl)glycine

: 215534-68-2
2,8-dibenzyl-6-methyl-2,3-dihydro-8H-pyrazino[1,2-a]pyrazine-1,4,7-trione

Guidance literature:: Multi-step reaction with 3 steps

1: EDCI; DMAP / CH₂Cl₂

2: 41 percent / CH₂Cl₂ / -78 °C

3: 77 percent / TFA

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane; 1: Condensation / 2: ozonolysis / 2: Condensation / 3: Cyclization;
DOI:10.1021/ol990355r