7-L-Alanylpaclitaxel

Base Information

Chemical Name:7-L-Alanylpaclitaxel
CAS No.:131966-79-5
Molecular Formula:C₅₀H₅₆N₂O₁₅
Molecular Weight:924.999
Hs Code.:
DSSTox Substance ID:DTXSID601315191

Synonyms:7-L-Alanylpaclitaxel;DTXSID601315191;131966-79-5

Suppliers and Price of 7-L-Alanylpaclitaxel

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 0 raw suppliers

Chemical Property of 7-L-Alanylpaclitaxel

Chemical Property:

XLogP3:2.6
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:16
Rotatable Bond Count:17
Exact Mass:924.36806908
Heavy Atom Count:67
Complexity:1970

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)OC(=O)C(C)N)C)OC(=O)C
Isomeric SMILES:CC1=C2[C@H](C(=O)[C@@]3([C@H](C[C@@H]4[C@]([C@H]3[C@@H]([C@@](C2(C)C)(C[C@@H]1OC(=O)[C@@H]([C@H](C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)OC(=O)[C@H](C)N)C)OC(=O)C

Technology Process of 7-L-Alanylpaclitaxel

There total 3 articles about 7-L-Alanylpaclitaxel which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 137234-35-6
2',7-di-L-alanyltaxol

: 131966-79-5
7-L-alanyltaxol

Guidance literature:: With phosphate buffer; In acetonitrile; for 12h; Ambient temperature;
DOI:10.1021/jm00079a019

Reference yield:

: 33069-62-4
taxol

: 131966-79-5
7-L-alanyltaxol

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / DCC, DMPA / CH₂Cl₂ / 24 h / Ambient temperature

2: 0.27 g / formic acid / 1.5 h / Ambient temperature

3: 63 percent / phosphate buffer (pH 7.4) / acetonitrile / 12 h / Ambient temperature

With formic acid; phosphate buffer; 0,2,4-dichlorophenyl-0-methylisopropylamidothiophosphate; dicyclohexyl-carbodiimide; In dichloromethane; acetonitrile;
DOI:10.1021/jm00079a019

Reference yield:

: 131966-83-1
2',7-bis(t-BOC-L-alanyl)taxol

: 131966-79-5
7-L-alanyltaxol

Guidance literature:: Multi-step reaction with 2 steps

1: 0.27 g / formic acid / 1.5 h / Ambient temperature

2: 63 percent / phosphate buffer (pH 7.4) / acetonitrile / 12 h / Ambient temperature

With formic acid; phosphate buffer; In acetonitrile;
DOI:10.1021/jm00079a019