N-[2-[[(tert-butylamino)carbonyl]amino]-3-phenyl-1,6-naphthyridin-7-yl]-N-(4-hydroxybutyl)acetamide

Base Information

• Chemical Name: N-[2-[[(tert-butylamino)carbonyl]amino]-3-phenyl-1,6-naphthyridin-7-yl]-N-(4-hydroxybutyl)acetamide
• CAS No.: 862370-54-5
• Molecular Formula: C₂₅H₃₁N₅O₃
• Molecular Weight: 449.553

Synonyms:N-[2-[[(tert-butylamino)carbonyl]amino]-3-phenyl-1,6-naphthyridin-7-yl]-N-(4-hydroxybutyl)acetamide

Chemical Property of N-[2-[[(tert-butylamino)carbonyl]amino]-3-phenyl-1,6-naphthyridin-7-yl]-N-(4-hydroxybutyl)acetamide

Chemical Property:

Purity/Quality:

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Technology Process of N-[2-[[(tert-butylamino)carbonyl]amino]-3-phenyl-1,6-naphthyridin-7-yl]-N-(4-hydroxybutyl)acetamide

There total 7 articles about N-[2-[[(tert-butylamino)carbonyl]amino]-3-phenyl-1,6-naphthyridin-7-yl]-N-(4-hydroxybutyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

N-[4-(benzyloxy)butyl]-N-[2-[[(tert-butylamino)carbonyl]amino]-3-phenyl-1,6-naphthyridin-7-yl]acetamide (862370-52-3) → N-[2-[[(tert-butylamino)carbonyl]amino]-3-phenyl-1,6-naphthyridin-7-yl]-N-(4-hydroxybutyl)acetamide (862370-54-5)

Guidance literature:

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; at 20 ℃; for 48h;

DOI:10.1021/jm0500931

Reference yield: 67.0%

N-[4-(benzyloxy)butyl]-N-[2-[[(tert-butylamino)carbonyl]amino]-3-phenyl-1,6-naphthyridin-7-yl]acetamide (862370-52-3) → N-[2-[(aminocarbonyl)amino]-3-phenyl-1,6-naphthyridin-7-yl]-N-(4-hydroxybutyl)acetamide + N-[2-[[(tert-butylamino)carbonyl]amino]-3-phenyl-1,6-naphthyridin-7-yl]-N-(4-hydroxybutyl)acetamide (862370-54-5)

Guidance literature:

With iron(III) chloride; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1021/jm0500931

Reference yield: 39.0%

N-[4-(benzyloxy)butyl]-N-[2-[[(tert-butylamino)carbonyl]amino]-3-phenyl-1,6-naphthyridin-7-yl]acetamide (862370-52-3) → N-[2-[[(tert-butylamino)carbonyl]amino]-3-phenyl-1,6-naphthyridin-7-yl]-N-(4-hydroxybutyl)acetamide (862370-54-5) + N-[2-[[(tert-butylamino)carbonyl]amino]-3-phenyl-3,4-dihydro-1,6-naphthyridin-7-yl]acetamide + N-[4-(benzyloxy)butyl]-N-[2-[[(tert-butylamino)carbonyl]amino]-3-phenyl-3,4-dihydro-1,6-naphthyridin-7-yl]acetamide

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; at 20 ℃; for 48h; under 3102.89 Torr;

DOI:10.1021/jm0500931

upstream raw materials:

N-[4-(benzyloxy)butyl]-N-[2-[[(tert-butylamino)carbonyl]amino]-3-phenyl-1,6-naphthyridin-7-yl]acetamide

N-[2-[[(tert-butylamino)carbonyl]amino]-3-phenyl-1,6-naphthyridin-7-yl]acetamide

3-Phenyl-1,6-naphthyridine-2,7-diamine

N-(7-amino-3-phenyl-1,6-naphthyridin-2-yl)-N'-tert-butylurea

Downstream raw materials:

methanesulfonic acid 4-{acetyl-[2-(3-tert-butyl-ureido)-3-phenyl-[1,6]naphthyridin-7-yl]-amino}-butyl ester

N-[2-[[(tert-butylamino)carbonyl]amino]-3-phenyl-1,6-naphthyridin-7-yl]-N-[4-(diethylamino)butyl]acetamide

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