8-(tert-butyldimethylsiloxy)-13-methoxy-4,4-bis(methoxycarbonyl)-9,9-dimethyl-1-phenyl-(1E)-tridecene-6,11-diyne

Base Information

Chemical Name:8-(tert-butyldimethylsiloxy)-13-methoxy-4,4-bis(methoxycarbonyl)-9,9-dimethyl-1-phenyl-(1E)-tridecene-6,11-diyne
CAS No.:138180-63-9
Molecular Formula:C₃₂H₄₆O₆Si
Molecular Weight:554.799
Hs Code.:

Synonyms:8-(tert-butyldimethylsiloxy)-13-methoxy-4,4-bis(methoxycarbonyl)-9,9-dimethyl-1-phenyl-(1E)-tridecene-6,11-diyne

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Chemical Property of 8-(tert-butyldimethylsiloxy)-13-methoxy-4,4-bis(methoxycarbonyl)-9,9-dimethyl-1-phenyl-(1E)-tridecene-6,11-diyne

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Technology Process of 8-(tert-butyldimethylsiloxy)-13-methoxy-4,4-bis(methoxycarbonyl)-9,9-dimethyl-1-phenyl-(1E)-tridecene-6,11-diyne

There total 5 articles about 8-(tert-butyldimethylsiloxy)-13-methoxy-4,4-bis(methoxycarbonyl)-9,9-dimethyl-1-phenyl-(1E)-tridecene-6,11-diyne which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 21087-29-6
trans-3-phenylprop-2-enyl chloride

: 138180-63-9
8-(tert-butyldimethylsiloxy)-13-methoxy-4,4-bis(methoxycarbonyl)-9,9-dimethyl-1-phenyl-(1E)-tridecene-6,11-diyne

Guidance literature:: Multi-step reaction with 4 steps

1: 87 percent / K₂CO₃ / acetone / 24 h / Heating

2: 1.) LiN(TMS)2 / 1.) THF, -78 deg C, 40 min, 2.) THF, -78 deg C, 1.5 h

3: 99 percent / 2,6-lutidine / CH₂Cl₂ / 2 h / 0 °C

4: 1.) LiN(TMS)2 / 1.) THF, -78 deg C, 1.5 h, 2.) THF, a) -78 deg C, 2 h, b) RT, 2.5 h

With 2,6-dimethylpyridine; potassium carbonate; lithium hexamethyldisilazane; In dichloromethane; acetone;
DOI:10.1021/ja00079a033

Reference yield:

: 95124-07-5
dimethyl (prop-2-yn-1-yl)malonate

: 138180-63-9
8-(tert-butyldimethylsiloxy)-13-methoxy-4,4-bis(methoxycarbonyl)-9,9-dimethyl-1-phenyl-(1E)-tridecene-6,11-diyne

Guidance literature:: Multi-step reaction with 4 steps

1: 87 percent / K₂CO₃ / acetone / 24 h / Heating

2: 1.) LiN(TMS)2 / 1.) THF, -78 deg C, 40 min, 2.) THF, -78 deg C, 1.5 h

3: 99 percent / 2,6-lutidine / CH₂Cl₂ / 2 h / 0 °C

4: 1.) LiN(TMS)2 / 1.) THF, -78 deg C, 1.5 h, 2.) THF, a) -78 deg C, 2 h, b) RT, 2.5 h

With 2,6-dimethylpyridine; potassium carbonate; lithium hexamethyldisilazane; In dichloromethane; acetone;
DOI:10.1021/ja00079a033

Reference yield:

: 130860-69-4
dimethyl 2-[(E)-cinnamyl]-2-propargylmalonate

: 138180-63-9
8-(tert-butyldimethylsiloxy)-13-methoxy-4,4-bis(methoxycarbonyl)-9,9-dimethyl-1-phenyl-(1E)-tridecene-6,11-diyne

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) LiN(TMS)2 / 1.) THF, -78 deg C, 40 min, 2.) THF, -78 deg C, 1.5 h

2: 99 percent / 2,6-lutidine / CH₂Cl₂ / 2 h / 0 °C

3: 1.) LiN(TMS)2 / 1.) THF, -78 deg C, 1.5 h, 2.) THF, a) -78 deg C, 2 h, b) RT, 2.5 h

With 2,6-dimethylpyridine; lithium hexamethyldisilazane; In dichloromethane;
DOI:10.1021/ja00079a033