N₁-[(3S)-1-(2-cyano-4-nitrophenyl)-3-pyrrolidinyl]-L-norleucinamide hydrochloride

Base Information

• Chemical Name: N₁-[(3S)-1-(2-cyano-4-nitrophenyl)-3-pyrrolidinyl]-L-norleucinamide hydrochloride
• CAS No.: 1269408-45-8
• Molecular Formula: C₁₇H₂₃N₅O₃*ClH
• Molecular Weight: 381.862

Synonyms:N₁-[(3S)-1-(2-cyano-4-nitrophenyl)-3-pyrrolidinyl]-L-norleucinamide hydrochloride

Chemical Property of N₁-[(3S)-1-(2-cyano-4-nitrophenyl)-3-pyrrolidinyl]-L-norleucinamide hydrochloride

Chemical Property:

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Technology Process of N₁-[(3S)-1-(2-cyano-4-nitrophenyl)-3-pyrrolidinyl]-L-norleucinamide hydrochloride

There total 4 articles about N₁-[(3S)-1-(2-cyano-4-nitrophenyl)-3-pyrrolidinyl]-L-norleucinamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

N1-[(3S)-1-(2-cyano-4-nitrophenyl)-3-pyrrolidinyl]-N2-{[(1,1-dimethylethyl)oxy]carbonyl}-L-norleucinamide (1269407-22-8) → N1-[(3S)-1-(2-cyano-4-nitrophenyl)-3-pyrrolidinyl]-L-norleucinamide hydrochloride (1269408-45-8)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 1h;

Reference yield:

2-fluoro-5-nitrobenzonitrile (17417-09-3) → N1-[(3S)-1-(2-cyano-4-nitrophenyl)-3-pyrrolidinyl]-L-norleucinamide hydrochloride (1269408-45-8)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate / acetonitrile / 1 h / 20 °C

2: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

3: triethylamine; HATU / dichloromethane / 2 h / 20 °C

4: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

With hydrogenchloride; potassium carbonate; triethylamine; HATU; In 1,4-dioxane; dichloromethane; acetonitrile;

Reference yield:

1,1-dimethylethyl [(3S)-1-(2-cyano-4-nitrophenyl)-3-pyrrolidinyl]carbamate (1269406-69-0) → N1-[(3S)-1-(2-cyano-4-nitrophenyl)-3-pyrrolidinyl]-L-norleucinamide hydrochloride (1269408-45-8)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

2: triethylamine; HATU / dichloromethane / 2 h / 20 °C

3: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

With hydrogenchloride; triethylamine; HATU; In 1,4-dioxane; dichloromethane;

upstream raw materials:

2-fluoro-5-nitrobenzonitrile

N₁-[(3S)-1-(2-cyano-4-nitrophenyl)-3-pyrrolidinyl]-N₂-{[(1,1-dimethylethyl)oxy]carbonyl}-L-norleucinamide

1,1-dimethylethyl [(3S)-1-(2-cyano-4-nitrophenyl)-3-pyrrolidinyl]carbamate

2-[(3S)-3-amino-1-pyrrolidinyl]-5-nitrobenzonitrile hydrochloride

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