(S)-2,2-dimethyl-5-(1-(4-((4'-(trifluoromethyl)biphenyl-3-yl)methoxy)phenyl)but-2-ynyl)-1,3-dioxane-4,6-dione

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Chemical Name:(S)-2,2-dimethyl-5-(1-(4-((4'-(trifluoromethyl)biphenyl-3-yl)methoxy)phenyl)but-2-ynyl)-1,3-dioxane-4,6-dione
CAS No.:1237025-63-6
Molecular Formula:C₃₀H₂₅F₃O₅
Molecular Weight:522.521
Hs Code.:

Synonyms:(S)-2,2-dimethyl-5-(1-(4-((4'-(trifluoromethyl)biphenyl-3-yl)methoxy)phenyl)but-2-ynyl)-1,3-dioxane-4,6-dione

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Chemical Property of (S)-2,2-dimethyl-5-(1-(4-((4'-(trifluoromethyl)biphenyl-3-yl)methoxy)phenyl)but-2-ynyl)-1,3-dioxane-4,6-dione

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Technology Process of (S)-2,2-dimethyl-5-(1-(4-((4'-(trifluoromethyl)biphenyl-3-yl)methoxy)phenyl)but-2-ynyl)-1,3-dioxane-4,6-dione

There total 2 articles about (S)-2,2-dimethyl-5-(1-(4-((4'-(trifluoromethyl)biphenyl-3-yl)methoxy)phenyl)but-2-ynyl)-1,3-dioxane-4,6-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1237025-66-9
2,2-dimethyl-5-(4-((4'-(trifluoromethyl)biphenyl-3-yl)methoxy)benzylidene)-1,3-dioxane-4,6-dione

: 104085-63-4
1-n-propynylmagnesium chloride

: 1237025-63-6
(S)-2,2-dimethyl-5-(1-(4-((4'-(trifluoromethyl)biphenyl-3-yl)methoxy)phenyl)but-2-ynyl)-1,3-dioxane-4,6-dione

: (R)-2,2-dimethyl-5-(1-(4-((4'-(trifluoromethyl)biphenyl-3-yl)methoxy)phenyl)but-2-ynyl)-1,3-dioxane-4,6-dione

Guidance literature:: 1-n-propynylmagnesium chloride; With 2,2,2-trifluoroethanol; cinchonidine; In tetrahydrofuran; water; toluene; at 0 - 20 ℃; for 1.08333h; Inert atmosphere;

2,2-dimethyl-5-(4-((4'-(trifluoromethyl)biphenyl-3-yl)methoxy)benzylidene)-1,3-dioxane-4,6-dione; In tetrahydrofuran; water; toluene; at 20 - 22 ℃; enantioselective reaction; Inert atmosphere;
DOI:10.1016/j.tet.2010.04.019

Reference yield: 17.0%

: 1204473-98-2
C₂₃H₂₁BrO₅

: 128796-39-4
4-trifluoromethylphenylboronic acid

: 1237025-63-6
(S)-2,2-dimethyl-5-(1-(4-((4'-(trifluoromethyl)biphenyl-3-yl)methoxy)phenyl)but-2-ynyl)-1,3-dioxane-4,6-dione

Guidance literature:: With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate monohydrate; palladium diacetate; In tetrahydrofuran; at 50 ℃; Inert atmosphere;
DOI:10.1016/j.tet.2010.04.019

Reference yield: 90.0%

: 1237025-63-6
(S)-2,2-dimethyl-5-(1-(4-((4'-(trifluoromethyl)biphenyl-3-yl)methoxy)phenyl)but-2-ynyl)-1,3-dioxane-4,6-dione

: sodium (S)-3-(4-{[4'-(trifluoromethyl)biphenyl-3-yl]methoxy}phenyl)hex-4-ynoate

Guidance literature:: (S)-2,2-dimethyl-5-(1-(4-((4'-(trifluoromethyl)biphenyl-3-yl)methoxy)phenyl)but-2-ynyl)-1,3-dioxane-4,6-dione; With water; In N,N-dimethyl-formamide; at 90 ℃; for 2h; Inert atmosphere;

With sodium hydroxide; In water; acetonitrile; at 20 ℃; Inert atmosphere;
DOI:10.1016/j.tet.2010.04.019