Technology Process of (1R,2R,3R)-1-(3,4-dimethoxyphenyl)-2,3-dimethyl-1-(tert-butyldimethylsiloxy)pentan-4,5-diol
There total 7 articles about (1R,2R,3R)-1-(3,4-dimethoxyphenyl)-2,3-dimethyl-1-(tert-butyldimethylsiloxy)pentan-4,5-diol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
osmium(VIII) oxide; water; 4-methylmorpholine N-oxide;
In
tert-butyl alcohol;
at 20 ℃;
for 48h;
DOI:10.1021/jo200968f
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 1H-imidazole / dichloromethane / 0 - 20 °C / Inert atmosphere
2: osmium(VIII) oxide; water; 4-methylmorpholine N-oxide / tert-butyl alcohol / 48 h / 20 °C
With
1H-imidazole; osmium(VIII) oxide; water; 4-methylmorpholine N-oxide;
In
dichloromethane; tert-butyl alcohol;
DOI:10.1021/jo200968f
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: acetic acid; zinc / 18 h / 60 °C
2.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 22 h / 0 - 20 °C / Inert atmosphere
3.1: tert.-butyl lithium / tetrahydrofuran; pentane / 0.17 h / -78 °C / Inert atmosphere
3.2: -78 - 20 °C / Inert atmosphere
4.1: sodium tetrahydroborate / methanol / -78 - 20 °C / Inert atmosphere
5.1: 1H-imidazole / dichloromethane / 0 - 20 °C / Inert atmosphere
6.1: osmium(VIII) oxide; water; 4-methylmorpholine N-oxide / tert-butyl alcohol / 48 h / 20 °C
With
1H-imidazole; dmap; sodium tetrahydroborate; osmium(VIII) oxide; water; tert.-butyl lithium; acetic acid; 4-methylmorpholine N-oxide; dicyclohexyl-carbodiimide; zinc;
In
tetrahydrofuran; methanol; dichloromethane; tert-butyl alcohol; pentane;
DOI:10.1021/jo200968f
