3-<2-(2,4-dichlorophenylamino)ethenyl>-4-ethoxycarbonylpyridazine

Base Information

• Chemical Name: 3-<2-(2,4-dichlorophenylamino)ethenyl>-4-ethoxycarbonylpyridazine
• CAS No.: 136411-58-0
• Molecular Formula: C₁₅H₁₃Cl₂N₃O₂
• Molecular Weight: 338.193
• Mol file: 136411-58-0.mol

Synonyms:3-<2-(2,4-dichlorophenylamino)ethenyl>-4-ethoxycarbonylpyridazine

Chemical Property of 3-<2-(2,4-dichlorophenylamino)ethenyl>-4-ethoxycarbonylpyridazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-<2-(2,4-dichlorophenylamino)ethenyl>-4-ethoxycarbonylpyridazine

There total 3 articles about 3-<2-(2,4-dichlorophenylamino)ethenyl>-4-ethoxycarbonylpyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

2,4-Dichloroaniline (554-00-7,51908-09-9) + ethyl 3-(2-dimethylaminoethenyl)methylpyridazine-4-carboxylic acid (136411-56-8) → 3-<2-(2,4-dichlorophenylamino)ethenyl>-4-ethoxycarbonylpyridazine (136411-58-0)

Guidance literature:

In dichloromethane; acetic acid; Ambient temperature;

Reference yield:

6-ethoxy-4-ethoxycarbonyl-1-methoxycarbonyl-3-methyl-1,4,5,6-tetrahydropyridazine (136411-55-7) → 3-<2-(2,4-dichlorophenylamino)ethenyl>-4-ethoxycarbonylpyridazine (136411-58-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 71 percent / HOAc, Br₂ / 24 h / 17 °C

2: 71 percent / dimethylformamide / 9 h / 110 °C

3: 82 percent / CH₂Cl₂; acetic acid / Ambient temperature

With bromine; acetic acid; In dichloromethane; acetic acid; N,N-dimethyl-formamide;

Reference yield:

ethyl 3-methylpyridazine-4-carboxylic acid (98832-80-5) → 3-<2-(2,4-dichlorophenylamino)ethenyl>-4-ethoxycarbonylpyridazine (136411-58-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 71 percent / dimethylformamide / 9 h / 110 °C

2: 82 percent / CH₂Cl₂; acetic acid / Ambient temperature

In dichloromethane; acetic acid; N,N-dimethyl-formamide;

upstream raw materials:

2,4-Dichloroaniline

ethyl 3-(2-dimethylaminoethenyl)methylpyridazine-4-carboxylic acid

ethyl 3-methylpyridazine-4-carboxylic acid

6-ethoxy-4-ethoxycarbonyl-1-methoxycarbonyl-3-methyl-1,4,5,6-tetrahydropyridazine

Downstream raw materials:

6-(2,4-dichlorophenyl)pyrido<4,3-c>pyridazin-5(6H)-one