1-(2-amino-4-decyl-phenyl)-3-(tert-butyl-dimethyl-silanyloxy)-propan-2-ol

Base Information

Chemical Name:1-(2-amino-4-decyl-phenyl)-3-(tert-butyl-dimethyl-silanyloxy)-propan-2-ol
CAS No.:442521-45-1
Molecular Formula:C₂₅H₄₇NO₂Si
Molecular Weight:421.739
Hs Code.:

1-(2-amino-4-decyl-phenyl)-3-(<i>tert</i>-butyl-dimethyl-silanyloxy)-propan-2-ol

Synonyms:1-(2-amino-4-decyl-phenyl)-3-(tert-butyl-dimethyl-silanyloxy)-propan-2-ol

Suppliers and Price of 1-(2-amino-4-decyl-phenyl)-3-(tert-butyl-dimethyl-silanyloxy)-propan-2-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(2-amino-4-decyl-phenyl)-3-(tert-butyl-dimethyl-silanyloxy)-propan-2-ol

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 1-(2-amino-4-decyl-phenyl)-3-(tert-butyl-dimethyl-silanyloxy)-propan-2-ol

There total 7 articles about 1-(2-amino-4-decyl-phenyl)-3-(tert-butyl-dimethyl-silanyloxy)-propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 442521-44-0
1-(tert-butyl-dimethyl-silanyloxy)-3-(4-dec-1-ynyl-2-nitro-phenyl)-propan-2-ol

: 442521-45-1
1-(2-amino-4-decyl-phenyl)-3-(tert-butyl-dimethyl-silanyloxy)-propan-2-ol

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; at 20 ℃; for 1h; under 760 Torr;
DOI:10.1016/S0040-4020(02)00099-6

Reference yield:

: 60956-26-5
4-bromo-2-nitrotoluene

: 442521-45-1
1-(2-amino-4-decyl-phenyl)-3-(tert-butyl-dimethyl-silanyloxy)-propan-2-ol

Guidance literature:: Multi-step reaction with 7 steps

1.1: NaH / tetrahydrofuran / 0.5 h / 0 °C

1.2: 87.6 percent / tetrahydrofuran / 24 h / 40 °C

2.1: 73.5 percent / LiBH₄ / tetrahydrofuran / 1 h / 20 °C

3.1: 81.7 percent / imidazole / dimethylformamide / 0 °C

4.1: 83.7 percent / pyridine / 1 h / 20 °C

5.1: PdCl₂(PPh₃)2; CuI; Et₂NH / 20 h / 20 °C

6.1: 599 mg / aq. NaOH / methanol / 1 h / 20 °C

7.1: 80 percent / H₂ / 10 percent Pd/C / ethanol / 1 h / 20 °C / 760 Torr

With pyridine; 1H-imidazole; bis-triphenylphosphine-palladium(II) chloride; sodium hydroxide; copper(l) iodide; lithium borohydride; hydrogen; sodium hydride; diethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide; 5.1: Sonagashira coupling;
DOI:10.1016/S0040-4020(02)00099-6

Reference yield:

: 442521-40-6
ethyl 3-(4-bromo-2-nitrophenyl)-2-oxopropanoate

: 442521-45-1
1-(2-amino-4-decyl-phenyl)-3-(tert-butyl-dimethyl-silanyloxy)-propan-2-ol

Guidance literature:: Multi-step reaction with 6 steps

1: 73.5 percent / LiBH₄ / tetrahydrofuran / 1 h / 20 °C

2: 81.7 percent / imidazole / dimethylformamide / 0 °C

3: 83.7 percent / pyridine / 1 h / 20 °C

4: PdCl₂(PPh₃)2; CuI; Et₂NH / 20 h / 20 °C

5: 599 mg / aq. NaOH / methanol / 1 h / 20 °C

6: 80 percent / H₂ / 10 percent Pd/C / ethanol / 1 h / 20 °C / 760 Torr

With pyridine; 1H-imidazole; bis-triphenylphosphine-palladium(II) chloride; sodium hydroxide; copper(l) iodide; lithium borohydride; hydrogen; diethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide; 4: Sonagashira coupling;
DOI:10.1016/S0040-4020(02)00099-6