1,2-dioxaspiro[2,5]octane-3-deoxy-3-[(4-fluorophenyl)thiourido]-5,6-O-isopropylidene-α-D-allofuranoside

Base Information

Chemical Name:1,2-dioxaspiro[2,5]octane-3-deoxy-3-[(4-fluorophenyl)thiourido]-5,6-O-isopropylidene-α-D-allofuranoside
CAS No.:1118979-74-0
Molecular Formula:C₂₂H₂₉FN₂O₅S
Molecular Weight:452.547
Hs Code.:

Synonyms:1,2-dioxaspiro[2,5]octane-3-deoxy-3-[(4-fluorophenyl)thiourido]-5,6-O-isopropylidene-α-D-allofuranoside

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Chemical Property of 1,2-dioxaspiro[2,5]octane-3-deoxy-3-[(4-fluorophenyl)thiourido]-5,6-O-isopropylidene-α-D-allofuranoside

Chemical Property:

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Technology Process of 1,2-dioxaspiro[2,5]octane-3-deoxy-3-[(4-fluorophenyl)thiourido]-5,6-O-isopropylidene-α-D-allofuranoside

There total 6 articles about 1,2-dioxaspiro[2,5]octane-3-deoxy-3-[(4-fluorophenyl)thiourido]-5,6-O-isopropylidene-α-D-allofuranoside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1118981-24-0
1,2-dioxa spiro[2,5]octane-3-deoxy-3-amino-5,6-O-isopropylidene-α-D-allofuranoside

: 1195-45-5
para-fluorophenyl isocyanate

: 1118979-74-0
1,2-dioxaspiro[2,5]octane-3-deoxy-3-[(4-fluorophenyl)thiourido]-5,6-O-isopropylidene-α-D-allofuranoside

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 6 - 7h;

Reference yield:

: 1118981-24-0
1,2-dioxa spiro[2,5]octane-3-deoxy-3-amino-5,6-O-isopropylidene-α-D-allofuranoside

: 1544-68-9
4-fluorophenyl isothiocyanate

: 1118979-74-0
1,2-dioxaspiro[2,5]octane-3-deoxy-3-[(4-fluorophenyl)thiourido]-5,6-O-isopropylidene-α-D-allofuranoside

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 6 - 7h;

Reference yield:

: 16832-21-6
1,2-O-cyclohexylidene-α-D-glucofuranose

: 1118979-74-0
1,2-dioxaspiro[2,5]octane-3-deoxy-3-[(4-fluorophenyl)thiourido]-5,6-O-isopropylidene-α-D-allofuranoside

Guidance literature:: Multi-step reaction with 5 steps

1.1: toluene-4-sulfonic acid / toluene / 1 h / Molecular sieve; Heating / reflux

2.1: acetic anhydride; dimethyl sulfoxide / 5 h / 70 - 80 °C

3.1: pyridine; hydroxylamine hydrochloride / ethanol / 7 - 8 h / 70 - 80 °C

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C

4.2: 0 °C

5.1: triethylamine / dichloromethane / 6 - 7 h / 20 °C

With pyridine; lithium aluminium tetrahydride; hydroxylamine hydrochloride; acetic anhydride; dimethyl sulfoxide; triethylamine; toluene-4-sulfonic acid; In tetrahydrofuran; ethanol; dichloromethane; toluene;