2-{2-[(S)-(+)-1-(2-(4-methylpiperazin-1-yl)acetoxy)]pentyl}benzoate-5-benzyloxy-1,4:3,6-dianhydro-D-glucitol

Base Information

Chemical Name:2-{2-[(S)-(+)-1-(2-(4-methylpiperazin-1-yl)acetoxy)]pentyl}benzoate-5-benzyloxy-1,4:3,6-dianhydro-D-glucitol
CAS No.:1428866-51-6
Molecular Formula:C₃₂H₄₂N₂O₇
Molecular Weight:566.695
Hs Code.:

Synonyms:2-{2-[(S)-(+)-1-(2-(4-methylpiperazin-1-yl)acetoxy)]pentyl}benzoate-5-benzyloxy-1,4:3,6-dianhydro-D-glucitol

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Chemical Property of 2-{2-[(S)-(+)-1-(2-(4-methylpiperazin-1-yl)acetoxy)]pentyl}benzoate-5-benzyloxy-1,4:3,6-dianhydro-D-glucitol

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Technology Process of 2-{2-[(S)-(+)-1-(2-(4-methylpiperazin-1-yl)acetoxy)]pentyl}benzoate-5-benzyloxy-1,4:3,6-dianhydro-D-glucitol

There total 5 articles about 2-{2-[(S)-(+)-1-(2-(4-methylpiperazin-1-yl)acetoxy)]pentyl}benzoate-5-benzyloxy-1,4:3,6-dianhydro-D-glucitol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1428866-50-5
C₁₉H₂₈N₂O₄

: 72631-67-5
(1R,4S,5R,8R)-8-benzyloxy-2,6-dioxabicyclo<3.3.0>octan-4-ol

: 1428866-51-6
2-{2-[(S)-(+)-1-(2-(4-methylpiperazin-1-yl)acetoxy)]pentyl}benzoate-5-benzyloxy-1,4:3,6-dianhydro-D-glucitol

Guidance literature:: C₁₉H₂₈N₂O₄; (1R,4S,5R,8R)-8-benzyloxy-2,6-dioxabicyclo<3.3.0>octan-4-ol; With dmap; In dichloromethane; at 0 ℃; for 0.166667h;

With dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 8h;
DOI:10.1021/jm4001693

Reference yield:

: 3413-15-8
(S)-3-n-butylphthalide

: 1428866-51-6
2-{2-[(S)-(+)-1-(2-(4-methylpiperazin-1-yl)acetoxy)]pentyl}benzoate-5-benzyloxy-1,4:3,6-dianhydro-D-glucitol

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide / water; methanol / 0.5 h / 50 °C

1.2: -10 - 0 °C

2.1: dmap; triethylamine / dichloromethane / 5 h / -10 °C

2.2: 1 h / 20 °C / pH 2

3.1: potassium carbonate / acetone / 8 h / 20 °C

4.1: dmap / dichloromethane / 0.17 h / 0 °C

4.2: 8 h / 20 °C

With dmap; potassium carbonate; triethylamine; sodium hydroxide; In methanol; dichloromethane; water; acetone;
DOI:10.1021/jm4001693

Reference yield:

: 3413-15-8,6066-49-5,93133-67-6,125412-70-6
butylphthalide

: 1428866-51-6
2-{2-[(S)-(+)-1-(2-(4-methylpiperazin-1-yl)acetoxy)]pentyl}benzoate-5-benzyloxy-1,4:3,6-dianhydro-D-glucitol

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide / water; methanol / 0.5 h / 50 °C

1.2: -10 - 0 °C

1.3: -20 - -10 °C

2.1: sodium hydroxide / water; methanol / 0.5 h / 50 °C

2.2: -10 - 0 °C

3.1: dmap; triethylamine / dichloromethane / 5 h / -10 °C

3.2: 1 h / 20 °C / pH 2

4.1: potassium carbonate / acetone / 8 h / 20 °C

5.1: dmap / dichloromethane / 0.17 h / 0 °C

5.2: 8 h / 20 °C

With dmap; potassium carbonate; triethylamine; sodium hydroxide; In methanol; dichloromethane; water; acetone;
DOI:10.1021/jm4001693