Benzenemethanamine, N-(2-bromophenyl)-a-methyl-, (aR)-

Base Information

• Chemical Name: Benzenemethanamine, N-(2-bromophenyl)-a-methyl-, (aR)-
• CAS No.: 873685-06-4
• Molecular Formula: C14H14 Br N
• Molecular Weight: 276.176
• Mol file: 873685-06-4.mol

Synonyms:Benzenemethanamine, N-(2-bromophenyl)-a-methyl-, (aR)-

Chemical Property of Benzenemethanamine, N-(2-bromophenyl)-a-methyl-, (aR)-

Chemical Property:

• Vapor Pressure: 3.34E-05mmHg at 25°C
• Refractive Index: 1.634
• Boiling Point: 354.5°C at 760 mmHg
• Flash Point: 168.2°C
• PSA: 12.03000
• Density: 1.36g/cm³
• LogP: 4.69520

Purity/Quality:

97% ^*data from raw suppliers

(ALPHA-R)-N-(2-BROMOPHENYL)-ALPHA-METHYL-BENZENEMETHANAMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenemethanamine, N-(2-bromophenyl)-a-methyl-, (aR)-

There total 1 articles about Benzenemethanamine, N-(2-bromophenyl)-a-methyl-, (aR)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

(R)-1-phenyl-ethyl-amine (3886-69-9) + 2,3-dibromobenzene (583-53-9) → (2-bromo-phenyl)-[(R)-1-phenyl-ethyl]-amine (873685-06-4)

Guidance literature:

With 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In toluene; at 95 ℃; for 45h;

DOI:10.1016/j.jorganchem.2005.07.024

Reference yield: 43.0%

(2-bromo-phenyl)-[(R)-1-phenyl-ethyl]-amine (873685-06-4) + (R)-1-phenyl-ethyl-amine (3886-69-9) → N,N'-bis[(R)-1-phenyl-ethyl]benzene-1,2-diamine (873685-07-5) + (R)-phenyl-(1-phenylethyl)amine (779-54-4,21232-36-0,21232-37-1,23652-68-8)

Guidance literature:

With 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In toluene; at 130 ℃; for 2h;

DOI:10.1016/j.jorganchem.2005.07.024

Reference yield:

(2-bromo-phenyl)-[(R)-1-phenyl-ethyl]-amine (873685-06-4) → N,N'-bis-(R)-α-methylbenzyl-benzimidazolium silver(I) chloride (873685-08-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 43 percent / racenic-BINAP; NaO(t-Bu) / Pd₂dba3*CHCl₃ / toluene / 2 h / 130 °C

2: 89 percent / HCl / H₂O / 20 - 80 °C

With hydrogenchloride; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In water; toluene;

DOI:10.1016/j.jorganchem.2005.07.024

upstream raw materials:

(R)-1-phenyl-ethyl-amine

2,3-dibromobenzene

Downstream raw materials:

N,N'-bis[(R)-1-phenyl-ethyl]benzene-1,2-diamine

(R)-phenyl-(1-phenylethyl)amine

N,N'-bis-(R)-α-methylbenzyl-benzimidazolium silver(I) chloride