(3S,4R)-tert-Butyl 3--5-((tert-butyldimethylsilyl)oxy)-4-methylpentanoate

Base Information

Chemical Name:(3S,4R)-tert-Butyl 3--5-((tert-butyldimethylsilyl)oxy)-4-methylpentanoate
CAS No.:162398-20-1
Molecular Formula:C₃₁H₄₉NO₃Si
Molecular Weight:511.82
Hs Code.:

(3S,4R)-tert-Butyl 3-<N-benzyl-N-((R)-1-phenylethyl)amino>-5-((tert-butyldimethylsilyl)oxy)-4-methylpentanoate

Synonyms:(3S,4R)-tert-Butyl 3--5-((tert-butyldimethylsilyl)oxy)-4-methylpentanoate

Suppliers and Price of (3S,4R)-tert-Butyl 3--5-((tert-butyldimethylsilyl)oxy)-4-methylpentanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3S,4R)-tert-Butyl 3--5-((tert-butyldimethylsilyl)oxy)-4-methylpentanoate

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Technology Process of (3S,4R)-tert-Butyl 3--5-((tert-butyldimethylsilyl)oxy)-4-methylpentanoate

There total 6 articles about (3S,4R)-tert-Butyl 3--5-((tert-butyldimethylsilyl)oxy)-4-methylpentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 38235-77-7
(R)-N-benzyl-1-phenylethylamine

: 138877-99-3
(R)-(E)-tert-Butyl 5-(tert-Butyldimethylsiloxy)-4-methyl-2-pentenoate

: 162398-20-1
(3S,4R)-tert-Butyl 3--5-((tert-butyldimethylsilyl)oxy)-4-methylpentanoate

Guidance literature:: With n-butyllithium; In tetrahydrofuran; hexane; 1.) 0 deg C, 30 min, 2.) -78 deg C, 2 h;
DOI:10.1021/jo00106a027

Reference yield:

: 3886-69-9
(R)-1-phenyl-ethyl-amine

: 162398-20-1
(3S,4R)-tert-Butyl 3--5-((tert-butyldimethylsilyl)oxy)-4-methylpentanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 67 percent / sodium cyanoborohydride, AcOH / methanol

2: 84 percent / n-BuLi / tetrahydrofuran; hexane / 1.) 0 deg C, 30 min, 2.) -78 deg C, 2 h

With n-butyllithium; sodium cyanoborohydride; acetic acid; In tetrahydrofuran; methanol; hexane;
DOI:10.1021/jo00106a027

Reference yield:

: 104701-87-3
(2S)-3-(tert-butyl-dimethyl-silyloxy)-2-methyl-propanal

: 162398-20-1
(3S,4R)-tert-Butyl 3--5-((tert-butyldimethylsilyl)oxy)-4-methylpentanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 43 percent / LDA / tetrahydrofuran; hexane / 1.) -78 deg C, 30 min, 2.) -78 deg C to r.t., 3 h

2: 84 percent / n-BuLi / tetrahydrofuran; hexane / 1.) 0 deg C, 30 min, 2.) -78 deg C, 2 h

With n-butyllithium; lithium diisopropyl amide; In tetrahydrofuran; hexane;
DOI:10.1021/jo00106a027