5-(2,3-dihydro-1,4-benzodioxane-6-yl)-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole

Base Information

• Chemical Name: 5-(2,3-dihydro-1,4-benzodioxane-6-yl)-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole
• CAS No.: 1350927-76-2
• Molecular Formula: C₁₇H₁₅FN₂O₂
• Molecular Weight: 298.317
• Mol file: 1350927-76-2.mol

Synonyms:5-(2,3-dihydro-1,4-benzodioxane-6-yl)-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole

Chemical Property of 5-(2,3-dihydro-1,4-benzodioxane-6-yl)-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(2,3-dihydro-1,4-benzodioxane-6-yl)-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole

There total 5 articles about 5-(2,3-dihydro-1,4-benzodioxane-6-yl)-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

(E)-3-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-1-(4-fluoro-phenyl)-propenone (93637-98-0) → 5-(2,3-dihydro-1,4-benzodioxane-6-yl)-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole (1350927-76-2)

Guidance literature:

With hydrazine hydrate; acetic acid; In ethanol; Reflux; Molecular sieve;

DOI:10.1016/j.bmcl.2011.10.056

Reference yield:

(E)-3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-(4-fluorophenyl)prop-2-en-1-one → 5-(2,3-dihydro-1,4-benzodioxane-6-yl)-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole (1350927-76-2)

Guidance literature:

With hydrazine hydrate; sodium hydroxide; In ethanol; for 4h; Reflux;

DOI:10.1016/j.ejmech.2018.06.043

Reference yield:

2,3-dihydro-benzo[1,4]dioxin-6-carbaldehyde (29668-44-8) → 5-(2,3-dihydro-1,4-benzodioxane-6-yl)-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole (1350927-76-2)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydroxide / ethanol; water / 0 - 20 °C

2: hydrazine hydrate; acetic acid / ethanol / Reflux; Molecular sieve

With hydrazine hydrate; acetic acid; potassium hydroxide; In ethanol; water; 1: Claisen Schmidt condensation;

DOI:10.1016/j.bmcl.2011.10.056

upstream raw materials:

2,3-dihydro-benzo[1,4]dioxin-6-carbaldehyde

(E)-3-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-1-(4-fluoro-phenyl)-propenone

3,4-dihydroxybenzaldehyde

1-(4-fluorophenyl)ethanone