{5-[4,5-Bis-(4-methoxy-phenyl)-1H-imidazol-2-ylsulfanyl]-pentyl}-[2-(2-methoxy-ethoxy)-ethyl]-amine

Base Information

Chemical Name:{5-[4,5-Bis-(4-methoxy-phenyl)-1H-imidazol-2-ylsulfanyl]-pentyl}-[2-(2-methoxy-ethoxy)-ethyl]-amine
CAS No.:1027220-25-2
Molecular Formula:C₂₇H₃₇N₃O₄S
Molecular Weight:499.674
Hs Code.:

Synonyms:{5-[4,5-Bis-(4-methoxy-phenyl)-1H-imidazol-2-ylsulfanyl]-pentyl}-[2-(2-methoxy-ethoxy)-ethyl]-amine

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Chemical Property of {5-[4,5-Bis-(4-methoxy-phenyl)-1H-imidazol-2-ylsulfanyl]-pentyl}-[2-(2-methoxy-ethoxy)-ethyl]-amine

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Technology Process of {5-[4,5-Bis-(4-methoxy-phenyl)-1H-imidazol-2-ylsulfanyl]-pentyl}-[2-(2-methoxy-ethoxy)-ethyl]-amine

There total 6 articles about {5-[4,5-Bis-(4-methoxy-phenyl)-1H-imidazol-2-ylsulfanyl]-pentyl}-[2-(2-methoxy-ethoxy)-ethyl]-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 162933-11-1
N-<2-(2-methoxyethoxy)ethyl>-5-<<4,5-bis(4-methoxyphenyl)-1H-imidazol-2-yl>thio>pentanamide

: 1027220-25-2
{5-[4,5-Bis-(4-methoxy-phenyl)-1H-imidazol-2-ylsulfanyl]-pentyl}-[2-(2-methoxy-ethoxy)-ethyl]-amine

Guidance literature:: With sodium bis(2-methoxyethoxy)aluminium dihydride; In toluene;
DOI:10.1021/jm00007a004

Reference yield:

: 111-77-3,95507-80-5
2-(2-methoxyethoxy)ethyl alcohol

: 1027220-25-2
{5-[4,5-Bis-(4-methoxy-phenyl)-1H-imidazol-2-ylsulfanyl]-pentyl}-[2-(2-methoxy-ethoxy)-ethyl]-amine

Guidance literature:: Multi-step reaction with 6 steps

1: PBr₃, pyridine / benzene / 56 h

2: sodium azide, NaI / dimethylformamide / 18 h / 60 °C

3: 1.) Ph₃P, 2.) H₂O / 1.) THF, RT, 10 h, 2.) THF, RT, 24 h

4: aq. K₂CO₃ / tetrahydrofuran / 4 h / Ambient temperature

5: 94 percent / K₂CO₃, tetra-n-butylammonium iodide / tetrahydrofuran / 2 h / Heating

6: 93 percent / sodium bis(2-methoxyethoxy)aluminum hydride / toluene

With pyridine; sodium azide; water; phosphorus tribromide; tetra-(n-butyl)ammonium iodide; potassium carbonate; triphenylphosphine; sodium bis(2-methoxyethoxy)aluminium dihydride; sodium iodide; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; benzene;
DOI:10.1021/jm00007a004

Reference yield:

: 54149-17-6,92450-98-1
2-bromoethyl 2-methoxyethyl ether

: 1027220-25-2
{5-[4,5-Bis-(4-methoxy-phenyl)-1H-imidazol-2-ylsulfanyl]-pentyl}-[2-(2-methoxy-ethoxy)-ethyl]-amine

Guidance literature:: Multi-step reaction with 5 steps

1: sodium azide, NaI / dimethylformamide / 18 h / 60 °C

2: 1.) Ph₃P, 2.) H₂O / 1.) THF, RT, 10 h, 2.) THF, RT, 24 h

3: aq. K₂CO₃ / tetrahydrofuran / 4 h / Ambient temperature

4: 94 percent / K₂CO₃, tetra-n-butylammonium iodide / tetrahydrofuran / 2 h / Heating

5: 93 percent / sodium bis(2-methoxyethoxy)aluminum hydride / toluene

With sodium azide; water; tetra-(n-butyl)ammonium iodide; potassium carbonate; triphenylphosphine; sodium bis(2-methoxyethoxy)aluminium dihydride; sodium iodide; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00007a004