(Z)-5-(2-fluoro-2-(3,4,5-trimethoxyphenyl)vinyl)-2-methoxyphenol

Base Information

• Chemical Name: (Z)-5-(2-fluoro-2-(3,4,5-trimethoxyphenyl)vinyl)-2-methoxyphenol
• CAS No.: 1021917-02-1
• Molecular Formula: C₁₈H₁₉FO₅
• Molecular Weight: 334.344
• Mol file: 1021917-02-1.mol

Synonyms:(Z)-5-(2-fluoro-2-(3,4,5-trimethoxyphenyl)vinyl)-2-methoxyphenol

Chemical Property of (Z)-5-(2-fluoro-2-(3,4,5-trimethoxyphenyl)vinyl)-2-methoxyphenol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-5-(2-fluoro-2-(3,4,5-trimethoxyphenyl)vinyl)-2-methoxyphenol

There total 7 articles about (Z)-5-(2-fluoro-2-(3,4,5-trimethoxyphenyl)vinyl)-2-methoxyphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

isovanillin (621-59-0) + 2-((fluoro(3,4,5-trimethoxyphenyl)methyl)sulfonyl)pyridine → (Z)-5-(2-fluoro-2-(3,4,5-trimethoxyphenyl)vinyl)-2-methoxyphenol (1021917-02-1)

Guidance literature:

With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide; at -55 - 20 ℃; for 6h; Inert atmosphere;

Reference yield: 51.0%

isovanillin (621-59-0) + 2-((fluoro(3,4,5-trimethoxyphenyl)methyl)sulfonyl)pyridine → (Z)-5-(2-fluoro-2-(3,4,5-trimethoxyphenyl)vinyl)-2-methoxyphenol (1021917-02-1) + C20H17FNO5S(1-)*Li(1+)

Guidance literature:

With lithium hexamethyldisilazane; In N,N,N,N,N,N-hexamethylphosphoric triamide; N,N-dimethyl-formamide; at -55 - 20 ℃; for 6h; Inert atmosphere;

DOI:10.1021/jacs.5b02112

Reference yield:

C24H33FO5Si → (Z)-5-(2-fluoro-2-(3,4,5-trimethoxyphenyl)vinyl)-2-methoxyphenol (1021917-02-1)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 20 ℃; for 2h;

DOI:10.1021/jm701362m

upstream raw materials:

isovanillin

5-[(E,Z)-2-fluoro-2-(3,4,5-trimethoxy-phenyl)-vinyl]-2-methoxy-phenol