N-((E)-(4S,11R)-4-[(R)-1-hydroxy-2-(3-isopropyl-benzylamino)-ethyl]-2,13-dioxo-11-phenyl-6-oxa-3,12-diaza-bicyclo[12.3.1]octadeca-1⁽¹⁸⁾,8,14,16-tetraen-16-yl)-N-methyl-methanesulfonamide

Base Information

• Chemical Name: N-((E)-(4S,11R)-4-[(R)-1-hydroxy-2-(3-isopropyl-benzylamino)-ethyl]-2,13-dioxo-11-phenyl-6-oxa-3,12-diaza-bicyclo[12.3.1]octadeca-1⁽¹⁸⁾,8,14,16-tetraen-16-yl)-N-methyl-methanesulfonamide
• CAS No.: 1385068-13-2
• Molecular Formula: C₃₅H₄₄N₄O₆S
• Molecular Weight: 648.824

Synonyms:N-((E)-(4S,11R)-4-[(R)-1-hydroxy-2-(3-isopropyl-benzylamino)-ethyl]-2,13-dioxo-11-phenyl-6-oxa-3,12-diaza-bicyclo[12.3.1]octadeca-1⁽¹⁸⁾,8,14,16-tetraen-16-yl)-N-methyl-methanesulfonamide

Chemical Property of N-((E)-(4S,11R)-4-[(R)-1-hydroxy-2-(3-isopropyl-benzylamino)-ethyl]-2,13-dioxo-11-phenyl-6-oxa-3,12-diaza-bicyclo[12.3.1]octadeca-1⁽¹⁸⁾,8,14,16-tetraen-16-yl)-N-methyl-methanesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-((E)-(4S,11R)-4-[(R)-1-hydroxy-2-(3-isopropyl-benzylamino)-ethyl]-2,13-dioxo-11-phenyl-6-oxa-3,12-diaza-bicyclo[12.3.1]octadeca-1⁽¹⁸⁾,8,14,16-tetraen-16-yl)-N-methyl-methanesulfonamide

There total 13 articles about N-((E)-(4S,11R)-4-[(R)-1-hydroxy-2-(3-isopropyl-benzylamino)-ethyl]-2,13-dioxo-11-phenyl-6-oxa-3,12-diaza-bicyclo[12.3.1]octadeca-1⁽¹⁸⁾,8,14,16-tetraen-16-yl)-N-methyl-methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

C32H37N3O9S2 + (3-isopropylphenyl)methanamine (110207-94-8) → N-((E)-(4S,11R)-4-[(R)-1-hydroxy-2-(3-isopropyl-benzylamino)-ethyl]-2,13-dioxo-11-phenyl-6-oxa-3,12-diaza-bicyclo[12.3.1]octadeca-1(18),8,14,16-tetraen-16-yl)-N-methyl-methanesulfonamide (1385068-13-2)

Guidance literature:

In ethanol; for 24h; Reflux;

DOI:10.1016/j.bmc.2012.05.039

Reference yield:

C30H39N3O7S → N-((E)-(4S,11R)-4-[(R)-1-hydroxy-2-(3-isopropyl-benzylamino)-ethyl]-2,13-dioxo-11-phenyl-6-oxa-3,12-diaza-bicyclo[12.3.1]octadeca-1(18),8,14,16-tetraen-16-yl)-N-methyl-methanesulfonamide (1385068-13-2)

Guidance literature:

Multi-step reaction with 4 steps

1: acetic acid / water / 1.75 h / 60 °C

2: Hoveyda-Grubbs catalyst second generation / dichloromethane / Inert atmosphere; Reflux

3: di(n-butyl)tin oxide; triethylamine / dichloromethane / 23 h / 20 °C

4: ethanol / 24 h / Reflux

With Hoveyda-Grubbs catalyst second generation; di(n-butyl)tin oxide; acetic acid; triethylamine; In ethanol; dichloromethane; water;

DOI:10.1016/j.bmc.2012.05.039

Reference yield:

(S)-2-(allyloxy)-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)ethanamine (1385068-39-2) → N-((E)-(4S,11R)-4-[(R)-1-hydroxy-2-(3-isopropyl-benzylamino)-ethyl]-2,13-dioxo-11-phenyl-6-oxa-3,12-diaza-bicyclo[12.3.1]octadeca-1(18),8,14,16-tetraen-16-yl)-N-methyl-methanesulfonamide (1385068-13-2)

Guidance literature:

Multi-step reaction with 5 steps

1.1: lithium hydroxide / 1,4-dioxane; water / 1.17 h / 20 °C

1.2: 16 h / 20 °C

2.1: acetic acid / water / 1.75 h / 60 °C

3.1: Hoveyda-Grubbs catalyst second generation / dichloromethane / Inert atmosphere; Reflux

4.1: di(n-butyl)tin oxide; triethylamine / dichloromethane / 23 h / 20 °C

5.1: ethanol / 24 h / Reflux

With Hoveyda-Grubbs catalyst second generation; di(n-butyl)tin oxide; acetic acid; triethylamine; lithium hydroxide; In 1,4-dioxane; ethanol; dichloromethane; water;

DOI:10.1016/j.bmc.2012.05.039

upstream raw materials:

(3-isopropylphenyl)methanamine

(S)-4-((S)-2-(allyloxy)-1-azidoethyl)-2,2-dimethyl-1,3-dioxolane

(S)-2-(allyloxy)-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)ethanamine

(R)-(1-azidobut-3-yn-1-yl)benzene

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1385068-13-2 N-((E)-(4S,11R)-4-[(R)-1-hydroxy-2-(3-isopropyl-benzylamino)-ethyl]-2,13-dioxo-11-phenyl-6-oxa-3,12-diaza-bicyclo[12.3.1]octadeca-1⁽¹⁸⁾,8,14,16-tetraen-16-yl)-N-methyl-methanesulfonamide

Send

Send

Metric Ton KG G Pound L ML

Send

Send