Pyrimidine, 5-bromo-2-ethyl- (9CI)

Base Information

• Chemical Name: Pyrimidine, 5-bromo-2-ethyl- (9CI)
• CAS No.: 873331-73-8
• Molecular Formula: C6H7BrN2
• Molecular Weight: 187.039
• Hs Code.: 2933599090
• Mol file: 873331-73-8.mol

Synonyms:Pyrimidine, 5-bromo-2-ethyl- (9CI);5-Bromo-2-ethylpyrimidine;PyriMidine, 5-broMo-2-ethyl-

Chemical Property of Pyrimidine, 5-bromo-2-ethyl- (9CI)

Chemical Property:

• Boiling Point: 211.751 °C at 760 mmHg
• PKA: 0.56±0.22(Predicted)
• Flash Point: 81.864 °C
• PSA: 25.78000
• Density: 1.498 g/cm³
• LogP: 1.80150
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

5-Bromo-2-ethylpyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyrimidine, 5-bromo-2-ethyl- (9CI)

There total 4 articles about Pyrimidine, 5-bromo-2-ethyl- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

diethylzinc (557-20-0) + 5-bromo-2-iodopyrimidine (183438-24-6) → 5-bromo-2-ethyl-pyrimidine (873331-73-8)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 0 ℃; for 0.5h; Inert atmosphere;

Reference yield: 38.0%

5-bromo-2-ethylpyrimidine-4-carboxylic acid (1235450-86-8) → 5-bromo-2-ethyl-pyrimidine (873331-73-8)

Guidance literature:

In xylene; for 2h; Reflux;

Reference yield: 36.0%

diethylzinc (557-20-0) + 5-Bromo-2-chloropyrimidine (32779-36-5) → 5-bromo-2-ethyl-pyrimidine (873331-73-8)

Guidance literature:

With 1,1'-bis(diphenylphosphino)ferrocene; palladium dichloride; In 1,4-dioxane; hexane; at 50 ℃; Inert atmosphere;

DOI:10.1021/jo801501e

upstream raw materials:

diethylzinc

5-Bromo-2-chloropyrimidine

5-bromo-2-ethylpyrimidine-4-carboxylic acid

5-bromo-2-iodopyrimidine

Downstream raw materials:

2-ethyl-5-benzyloxypyrimidine

(S)-1-(1-(2-ethylpyrimidin-5-yl)piperidin-4-yl)-3-(2-fluoro-4-(methylsulfonyl)phenylamino)pyrrolidin-2-one

C₁₅H₁₄N₂

C₁₄H₁₂N₂