4-(4-fluorophenyl)-6-[3-(4-fluorophenyl)-4R-(4-hydroxyphenyl)-2-oxo-oxazolidin-5S-yl]morpholin-3-one

Base Information

Chemical Name:4-(4-fluorophenyl)-6-[3-(4-fluorophenyl)-4R-(4-hydroxyphenyl)-2-oxo-oxazolidin-5S-yl]morpholin-3-one
CAS No.:1053173-25-3
Molecular Formula:C₂₅H₂₀F₂N₂O₅
Molecular Weight:466.441
Hs Code.:

Synonyms:4-(4-fluorophenyl)-6-[3-(4-fluorophenyl)-4R-(4-hydroxyphenyl)-2-oxo-oxazolidin-5S-yl]morpholin-3-one

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Chemical Property of 4-(4-fluorophenyl)-6-[3-(4-fluorophenyl)-4R-(4-hydroxyphenyl)-2-oxo-oxazolidin-5S-yl]morpholin-3-one

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Technology Process of 4-(4-fluorophenyl)-6-[3-(4-fluorophenyl)-4R-(4-hydroxyphenyl)-2-oxo-oxazolidin-5S-yl]morpholin-3-one

There total 10 articles about 4-(4-fluorophenyl)-6-[3-(4-fluorophenyl)-4R-(4-hydroxyphenyl)-2-oxo-oxazolidin-5S-yl]morpholin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1053173-85-5
6-[4-(4-benzyloxy-phenyl)-3-(4-fluorophenyl)-2-oxo-oxazolidin-5-yl]-4-(4-fluorophenyl)morpholin-3-one

: 1053173-25-3
4-(4-fluorophenyl)-6-[3-(4-fluorophenyl)-4R-(4-hydroxyphenyl)-2-oxo-oxazolidin-5S-yl]morpholin-3-one

Guidance literature:: With cyclohexene; palladium 10% on activated carbon; In ethanol; ethyl acetate; for 2h; Heating / reflux;

Reference yield:

: 4397-53-9
p-benzyloxybenzaldehyde

: 1053173-25-3
4-(4-fluorophenyl)-6-[3-(4-fluorophenyl)-4R-(4-hydroxyphenyl)-2-oxo-oxazolidin-5S-yl]morpholin-3-one

Guidance literature:: Multi-step reaction with 9 steps

1: L-proline / dimethyl sulfoxide / 96 h / 20 °C

2: triethylamine / dichloromethane / -78 - 20 °C

3: phenyltrimethylammonium tribromide / tetrahydrofuran / 0 - 20 °C

4: sodium tetrahydroborate / ethanol / 1 h / 0 °C

5: sodium t-butanolate / tetrahydrofuran / 1 h / 20 °C

6: lithium perchlorate / diethyl ether / 20 °C

7: triethylamine / dichloromethane / 1.5 h / 0 - 20 °C

8: caesium carbonate / N,N-dimethyl-formamide / 20 °C

9: cyclohexene / palladium 10% on activated carbon / ethanol; ethyl acetate / 2 h / Heating / reflux

With sodium tetrahydroborate; lithium perchlorate; phenyltrimethylammonium tribromide; caesium carbonate; triethylamine; sodium t-butanolate; cyclohexene; palladium 10% on activated carbon; L-proline; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: C₂₄H₁₉BrFNO₄

: 1053173-25-3
4-(4-fluorophenyl)-6-[3-(4-fluorophenyl)-4R-(4-hydroxyphenyl)-2-oxo-oxazolidin-5S-yl]morpholin-3-one

Guidance literature:: Multi-step reaction with 6 steps

1: sodium tetrahydroborate / ethanol / 1 h / 0 °C

2: sodium t-butanolate / tetrahydrofuran / 1 h / 20 °C

3: lithium perchlorate / diethyl ether / 20 °C

4: triethylamine / dichloromethane / 1.5 h / 0 - 20 °C

5: caesium carbonate / N,N-dimethyl-formamide / 20 °C

6: cyclohexene / palladium 10% on activated carbon / ethanol; ethyl acetate / 2 h / Heating / reflux

With sodium tetrahydroborate; lithium perchlorate; caesium carbonate; triethylamine; sodium t-butanolate; cyclohexene; palladium 10% on activated carbon; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;