4-(benzyloxy)-3-methoxy-5-(4-trifluoromethylphenoxy)benzaldehyde

Base Information

• Chemical Name: 4-(benzyloxy)-3-methoxy-5-(4-trifluoromethylphenoxy)benzaldehyde
• CAS No.: 1529796-67-5
• Molecular Formula: C₂₂H₁₇F₃O₄
• Molecular Weight: 402.37
• Mol file: 1529796-67-5.mol

Synonyms:4-(benzyloxy)-3-methoxy-5-(4-trifluoromethylphenoxy)benzaldehyde

Chemical Property of 4-(benzyloxy)-3-methoxy-5-(4-trifluoromethylphenoxy)benzaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 4-(benzyloxy)-3-methoxy-5-(4-trifluoromethylphenoxy)benzaldehyde

There total 3 articles about 4-(benzyloxy)-3-methoxy-5-(4-trifluoromethylphenoxy)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-Iodobenzotrifluoride (455-13-0) + 4-(benzyloxy)-3-hydroxy-5-methoxybenzaldehyde (1529796-54-0) → 4-(benzyloxy)-3-methoxy-5-(4-trifluoromethylphenoxy)benzaldehyde (1529796-67-5)

Guidance literature:

With 2-Picolinic acid; potassium phosphate; copper(l) iodide; In dimethyl sulfoxide; at 100 ℃; for 24h; Inert atmosphere;

DOI:10.1016/j.tetlet.2013.11.089

Reference yield:

5-hydroxyvanillin (3934-87-0) → 4-(benzyloxy)-3-methoxy-5-(4-trifluoromethylphenoxy)benzaldehyde (1529796-67-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydrogencarbonate; sodium iodide / N,N-dimethyl-formamide / 16 h / 40 °C

2: copper(l) iodide; potassium phosphate; 2-Picolinic acid / dimethyl sulfoxide / 24 h / 100 °C / Inert atmosphere

With 2-Picolinic acid; potassium phosphate; copper(l) iodide; sodium hydrogencarbonate; sodium iodide; In dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1016/j.tetlet.2013.11.089

Reference yield:

benzyl chloride (100-44-7) → 4-(benzyloxy)-3-methoxy-5-(4-trifluoromethylphenoxy)benzaldehyde (1529796-67-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydrogencarbonate; sodium iodide / N,N-dimethyl-formamide / 16 h / 40 °C

2: copper(l) iodide; potassium phosphate; 2-Picolinic acid / dimethyl sulfoxide / 24 h / 100 °C / Inert atmosphere

With 2-Picolinic acid; potassium phosphate; copper(l) iodide; sodium hydrogencarbonate; sodium iodide; In dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1016/j.tetlet.2013.11.089

upstream raw materials:

5-hydroxyvanillin

benzyl chloride

4-Iodobenzotrifluoride

4-(benzyloxy)-3-hydroxy-5-methoxybenzaldehyde