(S)-3-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenoxy)-5-((1-methyl-2-oxopyrrolidin-3-yl)oxy)-N-(thiazol-2-yl)benzamide

Base Information

Chemical Name:(S)-3-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenoxy)-5-((1-methyl-2-oxopyrrolidin-3-yl)oxy)-N-(thiazol-2-yl)benzamide
CAS No.:1263402-76-1
Molecular Formula:C₂₄H₂₁N₅O₅S
Molecular Weight:491.527
Hs Code.:

Synonyms:(S)-3-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenoxy)-5-((1-methyl-2-oxopyrrolidin-3-yl)oxy)-N-(thiazol-2-yl)benzamide

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Chemical Property of (S)-3-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenoxy)-5-((1-methyl-2-oxopyrrolidin-3-yl)oxy)-N-(thiazol-2-yl)benzamide

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Technology Process of (S)-3-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenoxy)-5-((1-methyl-2-oxopyrrolidin-3-yl)oxy)-N-(thiazol-2-yl)benzamide

There total 12 articles about (S)-3-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenoxy)-5-((1-methyl-2-oxopyrrolidin-3-yl)oxy)-N-(thiazol-2-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 96-50-4
2-thiazolylamine

: 1263403-98-0
S-(-)-3-[4-(5-methyl-1,3,4-oxadiazol-2-yl)phenoxy]-5-[(1-methyl-2-oxo-pyrrolidin-3-yl)oxy]benzoic acid

: 1263402-76-1
(S)-3-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenoxy)-5-((1-methyl-2-oxopyrrolidin-3-yl)oxy)-N-(thiazol-2-yl)benzamide

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 16.25h; Inert atmosphere;

Reference yield:

: 2150-44-9
1-carbomethoxy-3,5-dihydroxybenzene

: 1263402-76-1
(S)-3-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenoxy)-5-((1-methyl-2-oxopyrrolidin-3-yl)oxy)-N-(thiazol-2-yl)benzamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

2.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 90 °C / Inert atmosphere

3.1: Jones reagent / acetone / 0 °C

4.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0 - 5 °C

4.2: 0 - 20 °C / Inert atmosphere

5.1: thionyl chloride / toluene / 20 °C / Inert atmosphere; Reflux

6.1: hydrogen / palladium 10% on activated carbon / acetic acid / 6 h / 3102.97 Torr

7.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 20 °C

8.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 20 °C

9.1: sodium hydroxide; water / methanol / 20 °C

10.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 16.25 h / 20 °C / Inert atmosphere

With dmap; Jones reagent; thionyl chloride; oxalyl dichloride; di-isopropyl azodicarboxylate; water; hydrogen; sodium hydride; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; sodium hydroxide; palladium 10% on activated carbon; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; dichloromethane; acetic acid; N,N-dimethyl-formamide; acetone; toluene; 3.1: Jones Oxidation;

Reference yield:

: 459-57-4
4-fluorobenzaldehyde

: 1263402-76-1
(S)-3-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenoxy)-5-((1-methyl-2-oxopyrrolidin-3-yl)oxy)-N-(thiazol-2-yl)benzamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 90 °C / Inert atmosphere

2.1: Jones reagent / acetone / 0 °C

3.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0 - 5 °C

3.2: 0 - 20 °C / Inert atmosphere

4.1: thionyl chloride / toluene / 20 °C / Inert atmosphere; Reflux

5.1: hydrogen / palladium 10% on activated carbon / acetic acid / 6 h / 3102.97 Torr

6.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 20 °C

7.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 20 °C

8.1: sodium hydroxide; water / methanol / 20 °C

9.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 16.25 h / 20 °C / Inert atmosphere

With dmap; Jones reagent; thionyl chloride; oxalyl dichloride; di-isopropyl azodicarboxylate; water; hydrogen; sodium hydride; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; sodium hydroxide; palladium 10% on activated carbon; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; dichloromethane; acetic acid; N,N-dimethyl-formamide; acetone; toluene; 2.1: Jones Oxidation;