Technology Process of 2-(difluoromethyl)-5-(quinolin-3-yl)benzoic acid
There total 3 articles about 2-(difluoromethyl)-5-(quinolin-3-yl)benzoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium persulfate; silver nitrate; Selectfluor;
In
water; acetonitrile;
at 80 ℃;
for 10h;
Inert atmosphere;
Schlenk technique;
Cooling with liquid nitrogen;
DOI:10.1002/anie.201400225
- Guidance literature:
-
Multi-step reaction with 3 steps
1: potassium carbonate; palladium diacetate / water; 1,4-dioxane / 4 h / Inert atmosphere; Schlenk technique; Reflux
2: sodium hydroxide / ethanol / 50 °C / Inert atmosphere; Schlenk technique
3: sodium persulfate; Selectfluor; silver nitrate / acetonitrile; water / 10 h / 80 °C / Inert atmosphere; Schlenk technique; Cooling with liquid nitrogen
With
sodium persulfate; palladium diacetate; potassium carbonate; silver nitrate; Selectfluor; sodium hydroxide;
In
1,4-dioxane; ethanol; water; acetonitrile;
DOI:10.1002/anie.201400225
- Guidance literature:
-
Multi-step reaction with 3 steps
1: potassium carbonate; palladium diacetate / water; 1,4-dioxane / 4 h / Inert atmosphere; Schlenk technique; Reflux
2: sodium hydroxide / ethanol / 50 °C / Inert atmosphere; Schlenk technique
3: sodium persulfate; Selectfluor; silver nitrate / acetonitrile; water / 10 h / 80 °C / Inert atmosphere; Schlenk technique; Cooling with liquid nitrogen
With
sodium persulfate; palladium diacetate; potassium carbonate; silver nitrate; Selectfluor; sodium hydroxide;
In
1,4-dioxane; ethanol; water; acetonitrile;
DOI:10.1002/anie.201400225
