(Z)-Octadec-9-enoic acid [(S)-3-chloro-1-(4-hydroxy-benzyl)-2-oxo-propyl]-amide

Base Information

Chemical Name:(Z)-Octadec-9-enoic acid [(S)-3-chloro-1-(4-hydroxy-benzyl)-2-oxo-propyl]-amide
CAS No.:885021-69-2
Molecular Formula:C₂₈H₄₄ClNO₃
Molecular Weight:478.115
Hs Code.:

Synonyms:(Z)-Octadec-9-enoic acid [(S)-3-chloro-1-(4-hydroxy-benzyl)-2-oxo-propyl]-amide

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Chemical Property of (Z)-Octadec-9-enoic acid [(S)-3-chloro-1-(4-hydroxy-benzyl)-2-oxo-propyl]-amide

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Technology Process of (Z)-Octadec-9-enoic acid [(S)-3-chloro-1-(4-hydroxy-benzyl)-2-oxo-propyl]-amide

There total 3 articles about (Z)-Octadec-9-enoic acid [(S)-3-chloro-1-(4-hydroxy-benzyl)-2-oxo-propyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (1S)-1-amino-3-chloro-1-[(4-hydroxyphenyl)methyl]propan-2-one hydrochloride

: 112-80-1,2027-47-6
cis-Octadecenoic acid

: 885021-69-2
(Z)-Octadec-9-enoic acid [(S)-3-chloro-1-(4-hydroxy-benzyl)-2-oxo-propyl]-amide

Guidance literature:: cis-Octadecenoic acid; With 4-methyl-morpholine; isobutyl chloroformate; In tetrahydrofuran; at -15 ℃; for 0.25h;

(1S)-1-amino-3-chloro-1-[(4-hydroxyphenyl)methyl]propan-2-one hydrochloride; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 24h;
DOI:10.1021/jm051226l

Reference yield:

: 3978-80-1
Boc-Tyr-OH

: 885021-69-2
(Z)-Octadec-9-enoic acid [(S)-3-chloro-1-(4-hydroxy-benzyl)-2-oxo-propyl]-amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: isobutyl chloroformate; Et₃N / tetrahydrofuran / -15 - 20 °C

1.2: 68 percent / tetrahydrofuran; diethyl ether / 2 h / 20 °C

2.1: HCl / ethyl acetate / 48 h / 20 °C

3.1: isobutyl chloroformate; N-methylmorpholine / tetrahydrofuran / 0.25 h / -15 °C

3.2: 550 mg / tetrahydrofuran; dimethylformamide / 24 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; triethylamine; isobutyl chloroformate; In tetrahydrofuran; ethyl acetate;
DOI:10.1021/jm051226l

Reference yield:

: 103602-26-2
(1S)-N-tert-butoxycarbonyl-1-amino-3-azo-1-[(4-hydroxyphenyl)methyl]propan-2-one

: 885021-69-2
(Z)-Octadec-9-enoic acid [(S)-3-chloro-1-(4-hydroxy-benzyl)-2-oxo-propyl]-amide

Guidance literature:: Multi-step reaction with 2 steps

1.1: HCl / ethyl acetate / 48 h / 20 °C

2.1: isobutyl chloroformate; N-methylmorpholine / tetrahydrofuran / 0.25 h / -15 °C

2.2: 550 mg / tetrahydrofuran; dimethylformamide / 24 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; isobutyl chloroformate; In tetrahydrofuran; ethyl acetate;
DOI:10.1021/jm051226l