Ac-Ala-Asp(OBzl)-Lys(Z)-Pro-Asp(OBzl)-Met(O)-Gly-NHNH₂

Base Information

• Chemical Name: Ac-Ala-Asp(OBzl)-Lys(Z)-Pro-Asp(OBzl)-Met(O)-Gly-NHNH₂
• CAS No.: 131084-75-8
• Molecular Formula: C₅₃H₇₀N₁₀O₁₅S
• Molecular Weight: 1119.26
• Mol file: 131084-75-8.mol

Synonyms:Ac-Ala-Asp(OBzl)-Lys(Z)-Pro-Asp(OBzl)-Met(O)-Gly-NHNH₂

Chemical Property of Ac-Ala-Asp(OBzl)-Lys(Z)-Pro-Asp(OBzl)-Met(O)-Gly-NHNH₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Ac-Ala-Asp(OBzl)-Lys(Z)-Pro-Asp(OBzl)-Met(O)-Gly-NHNH₂

There total 14 articles about Ac-Ala-Asp(OBzl)-Lys(Z)-Pro-Asp(OBzl)-Met(O)-Gly-NHNH₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

Ac-Ala-Asp(OBzl)-Lys(Z)-Pro-Asp(OBzl)-Met(O)-Gly-NHNH-Troc (131084-74-7) → Ac-Ala-Asp(OBzl)-Lys(Z)-Pro-Asp(OBzl)-Met(O)-Gly-NHNH2 (131084-75-8)

Guidance literature:

With zinc; In acetic acid; for 12h; Ambient temperature;

DOI:10.1248/cpb.38.2301

Reference yield:

N-acetyl-L-alanine N-hydroxysuccinimide ester (56186-36-8) → Ac-Ala-Asp(OBzl)-Lys(Z)-Pro-Asp(OBzl)-Met(O)-Gly-NHNH2 (131084-75-8)

Guidance literature:

Multi-step reaction with 2 steps

1: N-methylmorpholine / dimethylformamide / Ambient temperature

2: 80 percent / Zn dust / acetic acid / 12 h / Ambient temperature

With 4-methyl-morpholine; zinc; In acetic acid; N,N-dimethyl-formamide;

DOI:10.1248/cpb.38.2301

Reference yield:

Nα-t-butoxycarbonylaspartic acid α-N-hydroxysuccinimide ester β-benzyl ester (13798-75-9) → Ac-Ala-Asp(OBzl)-Lys(Z)-Pro-Asp(OBzl)-Met(O)-Gly-NHNH2 (131084-75-8)

Guidance literature:

Multi-step reaction with 10 steps

1: N-methylmorpholine / dimethylformamide / Ambient temperature

2: TFA, anisole / ice-bath

3: N-methylmorpholine / dimethylformamide / Ambient temperature

4: TFA, anisole / ice-bath

5: N-methylmorpholine / dimethylformamide / Ambient temperature

6: TFA, anisole / ice-bath

7: NMM / dimethylformamide / Ambient temperature

8: TFA, anisole / ice-bath

9: N-methylmorpholine / dimethylformamide / Ambient temperature

10: 80 percent / Zn dust / acetic acid / 12 h / Ambient temperature

With 4-methyl-morpholine; methoxybenzene; trifluoroacetic acid; zinc; In acetic acid; N,N-dimethyl-formamide;

DOI:10.1248/cpb.38.2301

upstream raw materials:

Ac-Ala-Asp(OBzl)-Lys(Z)-Pro-Asp(OBzl)-Met(O)-Gly-NHNH-Troc

N-acetyl-L-alanine N-hydroxysuccinimide ester

N^α-t-butoxycarbonylaspartic acid α-N-hydroxysuccinimide ester β-benzyl ester

Boc-Met(O)-OSu