(2R,3R)-1-(triisopropylsiloxy)-2,4-[(R)-p-methoxybenzylidenedioxy]-3-methylbutane

Base Information

Chemical Name:(2R,3R)-1-(triisopropylsiloxy)-2,4-[(R)-p-methoxybenzylidenedioxy]-3-methylbutane
CAS No.:924889-76-9
Molecular Formula:C₂₂H₃₈O₄Si
Molecular Weight:394.627
Hs Code.:

Synonyms:(2R,3R)-1-(triisopropylsiloxy)-2,4-[(R)-p-methoxybenzylidenedioxy]-3-methylbutane

Suppliers and Price of (2R,3R)-1-(triisopropylsiloxy)-2,4-[(R)-p-methoxybenzylidenedioxy]-3-methylbutane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3R)-1-(triisopropylsiloxy)-2,4-[(R)-p-methoxybenzylidenedioxy]-3-methylbutane

Chemical Property:

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Technology Process of (2R,3R)-1-(triisopropylsiloxy)-2,4-[(R)-p-methoxybenzylidenedioxy]-3-methylbutane

There total 4 articles about (2R,3R)-1-(triisopropylsiloxy)-2,4-[(R)-p-methoxybenzylidenedioxy]-3-methylbutane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: methyl 3-hydroxy-4-(triisopropylsiloxy)-2-methylbutanoate

: 924889-76-9
(2R,3R)-1-(triisopropylsiloxy)-2,4-[(R)-p-methoxybenzylidenedioxy]-3-methylbutane

Guidance literature:: Multi-step reaction with 3 steps

1: 15 percent / DIBAL / CH₂Cl₂ / 1 h / 0 °C

2: 47 percent / DIBAL / CH₂Cl₂ / 1.5 h / 0 °C

3: CSA / CH₂Cl₂ / 2 h / 20 °C

With camphor-10-sulfonic acid; diisobutylaluminium hydride; In dichloromethane;
DOI:10.1002/chem.200500417

Reference yield:

: methyl (2R,3S)-3-hydroxy-4-(triisopropylsiloxy)-2-methyl-2-methylselenobutanoate

: 924889-76-9
(2R,3R)-1-(triisopropylsiloxy)-2,4-[(R)-p-methoxybenzylidenedioxy]-3-methylbutane

Guidance literature:: Multi-step reaction with 4 steps

1.1: iPr₂NEt; dibutylboron trifluoromethanesulfonate / toluene; CH₂Cl₂ / 0 - 20 °C

1.2: 77 percent / nBuSn₃H; Et₃B / toluene; hexane / 14 h / -78 °C

2.1: 15 percent / DIBAL / CH₂Cl₂ / 1 h / 0 °C

3.1: 47 percent / DIBAL / CH₂Cl₂ / 1.5 h / 0 °C

4.1: CSA / CH₂Cl₂ / 2 h / 20 °C

With di-n-butylboryl trifluoromethanesulfonate; camphor-10-sulfonic acid; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; In dichloromethane; toluene;
DOI:10.1002/chem.200500417

Reference yield:

: 111998-83-5
triisopropylsilyloxy-acetaldehyde

: 924889-76-9
(2R,3R)-1-(triisopropylsiloxy)-2,4-[(R)-p-methoxybenzylidenedioxy]-3-methylbutane

Guidance literature:: Multi-step reaction with 5 steps

1.1: (R)-1-methyl-2-(1-naphthylaminomethyl)pyrrolidine; Sn(OTf)2; nBu₃SnF / CH₂Cl₂ / 20 h / -78 °C

2.1: iPr₂NEt; dibutylboron trifluoromethanesulfonate / toluene; CH₂Cl₂ / 0 - 20 °C

2.2: 77 percent / nBuSn₃H; Et₃B / toluene; hexane / 14 h / -78 °C

3.1: 15 percent / DIBAL / CH₂Cl₂ / 1 h / 0 °C

4.1: 47 percent / DIBAL / CH₂Cl₂ / 1.5 h / 0 °C

5.1: CSA / CH₂Cl₂ / 2 h / 20 °C

With tin(II) trifluoromethanesulfonate; N-(((R)-1-methylpyrrolidin-2-yl)methyl)naphthalen-1-amine; di-n-butylboryl trifluoromethanesulfonate; camphor-10-sulfonic acid; diisobutylaluminium hydride; tributyltin fluoride; N-ethyl-N,N-diisopropylamine; In dichloromethane; toluene;
DOI:10.1002/chem.200500417