(1S,4R,5R)-2-Aza-tricyclo[3.2.1.0^2,4]oct-6-ene-4-carboxylic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

Base Information

• Chemical Name: (1S,4R,5R)-2-Aza-tricyclo[3.2.1.0^2,4]oct-6-ene-4-carboxylic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester
• CAS No.: 615283-07-3
• Molecular Formula: C₂₄H₃₁NO₂
• Molecular Weight: 365.516
• Mol file: 615283-07-3.mol

Synonyms:(1S,4R,5R)-2-Aza-tricyclo[3.2.1.0^2,4]oct-6-ene-4-carboxylic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

Chemical Property of (1S,4R,5R)-2-Aza-tricyclo[3.2.1.0^2,4]oct-6-ene-4-carboxylic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,4R,5R)-2-Aza-tricyclo[3.2.1.0^2,4]oct-6-ene-4-carboxylic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

There total 1 articles about (1S,4R,5R)-2-Aza-tricyclo[3.2.1.0^2,4]oct-6-ene-4-carboxylic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cyclopenta-1,3-diene (542-92-7,25568-84-7,7313-32-8) + (1R,2S,5R)-2-(1-methyl-1-phenylethyl)-5-methylcyclohexyl 2H-azirine-3-carboxylate (600734-37-0) → (1R,4S,5S)-2-Aza-tricyclo[3.2.1.02,4]oct-6-ene-4-carboxylic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester + (1S,4R,5R)-2-Aza-tricyclo[3.2.1.02,4]oct-6-ene-4-carboxylic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester (615283-07-3)

Guidance literature:

With magnesium bromide; In dichloromethane; at -100 ℃; Further Variations:; Reagents; Temperatures; Product distribution;

DOI:10.1039/b300849e

Reference yield: 55.0%

(1S,4R,5R)-2-Aza-tricyclo[3.2.1.02,4]oct-6-ene-4-carboxylic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester (615283-07-3) → (1S,4S,5R)-4-Chloro-2-aza-bicyclo[3.2.1]oct-6-ene-4-carboxylic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

Guidance literature:

With magnesium chloride; In dichloromethane; at -65 ℃; for 2h;

DOI:10.1021/jo0352326

Reference yield: 45.0%

(1S,4R,5R)-2-Aza-tricyclo[3.2.1.02,4]oct-6-ene-4-carboxylic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester (615283-07-3) → (1S,4S,5R)-4-Iodo-2-aza-bicyclo[3.2.1]oct-6-ene-4-carboxylic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

Guidance literature:

With magnesium iodide; In dichloromethane; at -65 ℃; for 2h;

DOI:10.1021/jo0352326

upstream raw materials:

cyclopenta-1,3-diene

(1R,2S,5R)-2-(1-methyl-1-phenylethyl)-5-methylcyclohexyl 2H-azirine-3-carboxylate