2-n-butyl-5-chloro-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid 3-(3,4-dihydroxyphenyl)propyl ester

Base Information

Chemical Name:2-n-butyl-5-chloro-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid 3-(3,4-dihydroxyphenyl)propyl ester
CAS No.:1370339-78-8
Molecular Formula:C₃₁H₃₁ClN₆O₄
Molecular Weight:587.078
Hs Code.:

Synonyms:2-n-butyl-5-chloro-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid 3-(3,4-dihydroxyphenyl)propyl ester

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Chemical Property of 2-n-butyl-5-chloro-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid 3-(3,4-dihydroxyphenyl)propyl ester

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Technology Process of 2-n-butyl-5-chloro-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid 3-(3,4-dihydroxyphenyl)propyl ester

There total 7 articles about 2-n-butyl-5-chloro-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid 3-(3,4-dihydroxyphenyl)propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1370339-76-6
2-n-butyl-5-chloro-3-[2'-(2-trityl-2H-tetrazol-5-yl)biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid 3-(3,4-bis-benzyloxyphenyl)propyl ester

: 1370339-78-8
2-n-butyl-5-chloro-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid 3-(3,4-dihydroxyphenyl)propyl ester

Guidance literature:: With 30% Pd/C; hydrogen; In methanol; chloroform; at 20 ℃; for 1.66667h; under 760.051 Torr;
DOI:10.1016/j.ejmech.2012.01.043

Reference yield:

: 1370339-75-5
2-n-butyl-5-chloro-3H-imidazole-4-carboxylic acid 3-(3,4-bisbenzyloxyphenyl)propyl ester

: 1370339-78-8
2-n-butyl-5-chloro-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid 3-(3,4-dihydroxyphenyl)propyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: tetrabutyl phosphonium bromide; sodium hydroxide / dichloromethane; water / 24 h / 20 °C

2: 30% Pd/C; hydrogen / methanol; chloroform / 1.67 h / 20 °C / 760.05 Torr

With 30% Pd/C; hydrogen; tetrabutyl phosphonium bromide; sodium hydroxide; In methanol; dichloromethane; chloroform; water;
DOI:10.1016/j.ejmech.2012.01.043

Reference yield:

: 1078-61-1
dihydrocaffeic acid

: 1370339-78-8
2-n-butyl-5-chloro-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid 3-(3,4-dihydroxyphenyl)propyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 20 h / 60 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 2.5 h / 0 - 20 °C

2.2: pH 1

3.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; diethyl ether / 12 h / 20 °C

4.1: tetrabutyl phosphonium bromide; sodium hydroxide / dichloromethane; water / 24 h / 20 °C

5.1: 30% Pd/C; hydrogen / methanol; chloroform / 1.67 h / 20 °C / 760.05 Torr

With lithium aluminium tetrahydride; 30% Pd/C; hydrogen; tetrabutyl phosphonium bromide; potassium carbonate; triphenylphosphine; sodium hydroxide; diethylazodicarboxylate; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2012.01.043