N-((R)-5-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyl-octahydro-1H-inden-1-yl)hexyl)-2-bromoacetamide

Base Information

Chemical Name:N-((R)-5-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyl-octahydro-1H-inden-1-yl)hexyl)-2-bromoacetamide
CAS No.:1188931-99-8
Molecular Formula:C₃₈H₇₀BrNO₃Si₂
Molecular Weight:725.054
Hs Code.:

N-((R)-5-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyl-octahydro-1H-inden-1-yl)hexyl)-2-bromoacetamide

Synonyms:N-((R)-5-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyl-octahydro-1H-inden-1-yl)hexyl)-2-bromoacetamide

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Chemical Property of N-((R)-5-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyl-octahydro-1H-inden-1-yl)hexyl)-2-bromoacetamide

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Technology Process of N-((R)-5-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyl-octahydro-1H-inden-1-yl)hexyl)-2-bromoacetamide

There total 6 articles about N-((R)-5-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyl-octahydro-1H-inden-1-yl)hexyl)-2-bromoacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1188931-91-0
(R)-5-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyl-octahydro-1H-inden-1-yl)hexan-1-amine

: 79-08-3
bromoacetic acid

: 1188931-99-8
N-((R)-5-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyl-octahydro-1H-inden-1-yl)hexyl)-2-bromoacetamide

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 20 ℃;

Reference yield:

: (S)-5-((1R,3aR,4S,7aR)-4-(tert-butyldimethylsilyloxy)-7a-methyloctahydro-1H-inden-1-yl)-1-ethoxyhex-1-ene

: 1188931-99-8
N-((R)-5-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyl-octahydro-1H-inden-1-yl)hexyl)-2-bromoacetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridinium chlorochromate / dichloromethane / 3 h / Molecular sieve

1.2: 24 h / 20 °C

1.3: 3 h / 20 °C / Molecular sieve

2.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.08 h / -78 °C / Inert atmosphere; Cooling with ice

2.2: 3.08 h / -78 - 20 °C / Inert atmosphere

2.3: Saturated solution

3.1: diisobutylaluminium hydride / dichloromethane; toluene / -78 - 20 °C / Inert atmosphere

4.1: O-benzylhydoxylamine hydrochloride; sodium acetate / toluene / 0.5 h / Reflux

4.2: 0 - 20 °C / Inert atmosphere

5.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 0 - 20 °C

With dmap; O-benzylhydoxylamine hydrochloride; sodium acetate; sodium hexamethyldisilazane; diisobutylaluminium hydride; dicyclohexyl-carbodiimide; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; toluene;

Reference yield:

: 1188931-89-6
(R)-ethyl-5-((1R,3aR,7aR)-7a-methyl-4-oxo-octahydro-1H-inden-1-yl)hexanoate

: 1188931-99-8
N-((R)-5-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyl-octahydro-1H-inden-1-yl)hexyl)-2-bromoacetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.08 h / -78 °C / Inert atmosphere; Cooling with ice

1.2: 3.08 h / -78 - 20 °C / Inert atmosphere

1.3: Saturated solution

2.1: diisobutylaluminium hydride / dichloromethane; toluene / -78 - 20 °C / Inert atmosphere

3.1: O-benzylhydoxylamine hydrochloride; sodium acetate / toluene / 0.5 h / Reflux

3.2: 0 - 20 °C / Inert atmosphere

4.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 0 - 20 °C

With dmap; O-benzylhydoxylamine hydrochloride; sodium acetate; sodium hexamethyldisilazane; diisobutylaluminium hydride; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; toluene;