N-(3-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)phenyl)cyclohexane carboxamide

Base Information

Chemical Name:N-(3-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)phenyl)cyclohexane carboxamide
CAS No.:1477503-76-6
Molecular Formula:C₂₁H₁₉ClF₃N₃O
Molecular Weight:421.85
Hs Code.:

Synonyms:N-(3-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)phenyl)cyclohexane carboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(3-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)phenyl)cyclohexane carboxamide

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Technology Process of N-(3-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)phenyl)cyclohexane carboxamide

There total 5 articles about N-(3-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)phenyl)cyclohexane carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 860785-05-3
C₁₄H₉ClF₃N₃

: 2719-27-9
cyclohexanylcarbonyl chloride

: 1477503-76-6
N-(3-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)phenyl)cyclohexane carboxamide

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 20 ℃; for 3h; Cooling with ice;
DOI:10.1007/s12272-013-0253-9

Reference yield:

: 2227-64-7
3'-nitro-2-bromoacetophenone

: 1477503-76-6
N-(3-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)phenyl)cyclohexane carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: N,N'-ditosylhydrazine; 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 20 °C

2: copper(II) bis(trifluoromethanesulfonate) / 1,2-dichloro-ethane / 80 °C

3: tin(ll) chloride; hydrogenchloride / ethanol / Reflux

4: triethylamine; dmap / dichloromethane / 3 h / 20 °C / Cooling with ice

With hydrogenchloride; dmap; N,N'-ditosylhydrazine; copper(II) bis(trifluoromethanesulfonate); 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; tin(ll) chloride; In tetrahydrofuran; ethanol; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1007/s12272-013-0253-9

Reference yield:

: 121-89-1
3-Nitroacetophenone

: 1477503-76-6
N-(3-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)phenyl)cyclohexane carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: pyridinium hydrobromide perbromide / acetic acid / Reflux

2: N,N'-ditosylhydrazine; 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 20 °C

3: copper(II) bis(trifluoromethanesulfonate) / 1,2-dichloro-ethane / 80 °C

4: tin(ll) chloride; hydrogenchloride / ethanol / Reflux

5: triethylamine; dmap / dichloromethane / 3 h / 20 °C / Cooling with ice

With hydrogenchloride; dmap; N,N'-ditosylhydrazine; pyridinium hydrobromide perbromide; copper(II) bis(trifluoromethanesulfonate); 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; tin(ll) chloride; In tetrahydrofuran; ethanol; dichloromethane; acetic acid; 1,2-dichloro-ethane;
DOI:10.1007/s12272-013-0253-9