ABI-286

Base Information

• Chemical Name: ABI-286
• CAS No.: 1253697-97-0
• Molecular Formula: C₁₉H₁₇ClN₂O₄
• Molecular Weight: 372.808
• Mol file: 1253697-97-0.mol

Synonyms:ABI-286

Chemical Property of ABI-286

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ABI-286

There total 6 articles about ABI-286 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.9%

(2-(4-chlorophenyl)-1-(phenylsulfonyl)-1H-imidazol-4-yl)(3,4,5-trimethoxyphenyl)methanone (1253697-73-2) → ABI-286 (1253697-97-0)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃;

DOI:10.1021/jm100884b

Reference yield: 36.9%

→ ABI-286 (1253697-97-0)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran;

Reference yield:

4-chlorobenzaldehyde (104-88-1) → ABI-286 (1253697-97-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: ammonium hydroxide / ethanol; water / 0 - 20 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

3.1: tert.-butyl lithium / tetrahydrofuran; pentane / 0.17 h / -78 °C

3.2: -78 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran

With ammonium hydroxide; tetrabutyl ammonium fluoride; tert.-butyl lithium; sodium hydride; In tetrahydrofuran; ethanol; water; mineral oil; pentane;

upstream raw materials:

(2-(4-chlorophenyl)-1-(phenylsulfonyl)-1H-imidazol-4-yl)(3,4,5-trimethoxyphenyl)methanone

4-chlorobenzaldehyde

2-(4-chlorophenyl)-1H-imidazole

2-(4-chlorophenyl)-1-(phenylsulfonyl)-1H-imidazole

Downstream raw materials:

(2-(4-chlorophenyl)-1H-imidazol-4-yl)(3,4,5-trihydroxyphenyl)methanone

(2-(4-chlorophenyl)-1H-imidazol-4-yl)(4-hydroxy-3,5-dimethoxyphenyl)methanone

Refernces

• 1、 -. "COMPOUNDS FOR TREATMENT OF CANCER". Paragraph 0041; 0046; 00359; 00382. . Retrieved 2011/10/03.