(R)-4-((7-(benzylamino)-2,3-dihydro-1,4-benzodioxin-2-yl)methoxy)benzonitrile

Base Information

Chemical Name:(R)-4-((7-(benzylamino)-2,3-dihydro-1,4-benzodioxin-2-yl)methoxy)benzonitrile
CAS No.:1430559-26-4
Molecular Formula:C₂₃H₂₀N₂O₃
Molecular Weight:372.423
Hs Code.:

Synonyms:(R)-4-((7-(benzylamino)-2,3-dihydro-1,4-benzodioxin-2-yl)methoxy)benzonitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-4-((7-(benzylamino)-2,3-dihydro-1,4-benzodioxin-2-yl)methoxy)benzonitrile

Chemical Property:

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Technology Process of (R)-4-((7-(benzylamino)-2,3-dihydro-1,4-benzodioxin-2-yl)methoxy)benzonitrile

There total 5 articles about (R)-4-((7-(benzylamino)-2,3-dihydro-1,4-benzodioxin-2-yl)methoxy)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₃H₁₈N₂O₃

: 1430559-26-4
(R)-4-((7-(benzylamino)-2,3-dihydro-1,4-benzodioxin-2-yl)methoxy)benzonitrile

Guidance literature:: With sodium tetrahydroborate; In methanol; for 1h;
DOI:10.1016/j.ejmech.2013.01.002

Reference yield:

: 157692-44-9
(R)-(7-nitro-2,3-dihydro-1,4-benzodioxin-2-yl)methanol

: 1430559-26-4
(R)-4-((7-(benzylamino)-2,3-dihydro-1,4-benzodioxin-2-yl)methoxy)benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 48.5 h / 0 °C / Inert atmosphere; Reflux

2: palladium 10% on activated carbon; sodium tetrahydroborate / methanol / 1 h / 20 °C / 18751.9 Torr

3: methanol / 12 h / 20 °C / Molecular sieve; Inert atmosphere

4: sodium tetrahydroborate / methanol / 1 h

With sodium tetrahydroborate; di-isopropyl azodicarboxylate; palladium 10% on activated carbon; triphenylphosphine; In tetrahydrofuran; methanol; 1: |Mitsunobu Displacement;
DOI:10.1016/j.ejmech.2013.01.002

Reference yield:

: 767-00-0
4-cyanophenol

: 1430559-26-4
(R)-4-((7-(benzylamino)-2,3-dihydro-1,4-benzodioxin-2-yl)methoxy)benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 48.5 h / 0 °C / Inert atmosphere; Reflux

2: palladium 10% on activated carbon; sodium tetrahydroborate / methanol / 1 h / 20 °C / 18751.9 Torr

3: methanol / 12 h / 20 °C / Molecular sieve; Inert atmosphere

4: sodium tetrahydroborate / methanol / 1 h

With sodium tetrahydroborate; di-isopropyl azodicarboxylate; palladium 10% on activated carbon; triphenylphosphine; In tetrahydrofuran; methanol; 1: |Mitsunobu Displacement;
DOI:10.1016/j.ejmech.2013.01.002