-O-<-L-valyl>-D-seryl>-N-methyl-L-alanine 2,2,2-Trichloroethyl Ester

Base Information

Chemical Name:-O-<-L-valyl>-D-seryl>-N-methyl-L-alanine 2,2,2-Trichloroethyl Ester
CAS No.:78186-12-6
Molecular Formula:C₂₈H₄₀Cl₃N₅O₉S
Molecular Weight:729.079
Hs Code.:

<N-<(Benzyloxy)carbonyl>-O-<<S-(acetamidomethyl)-L-cysteinyl>-L-valyl>-D-seryl>-N-methyl-L-alanine 2,2,2-Trichloroethyl Ester

Synonyms:-O-<-L-valyl>-D-seryl>-N-methyl-L-alanine 2,2,2-Trichloroethyl Ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of -O-<-L-valyl>-D-seryl>-N-methyl-L-alanine 2,2,2-Trichloroethyl Ester

Chemical Property:

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Technology Process of -O-<-L-valyl>-D-seryl>-N-methyl-L-alanine 2,2,2-Trichloroethyl Ester

There total 5 articles about -O-<-L-valyl>-D-seryl>-N-methyl-L-alanine 2,2,2-Trichloroethyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 78166-94-6
-O-<<(tert-butyloxy)carbonyl>-S-(acetamidomethyl)-L-cysteinyl-L-valyl>-D-seryl>-N-methyl-L-alanine 2,2,2-Trichloroethyl Ester

: 78186-12-6
-O-<-L-valyl>-D-seryl>-N-methyl-L-alanine 2,2,2-Trichloroethyl Ester

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 0.5h; Ambient temperature;
DOI:10.1021/jo00330a010

Reference yield:

: 78166-91-3
N-Methyl-L-alanine 2,2,2-Trichloroethyl Ester Hydrobromide

: 78186-12-6
-O-<-L-valyl>-D-seryl>-N-methyl-L-alanine 2,2,2-Trichloroethyl Ester

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / CH₂Cl₂ / 0.08 h / 0 °C

2: 88 percent / Et₃N / CH₂Cl₂ / 60 h / Ambient temperature

3: 87.5 percent / 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / 4-(dimethylamino)pyridine / CH₂Cl₂ / 1.) 0 deg C, 3 h, 2.) room temperature, overnight

4: 1.)trifluoroacetic acid, 2.) 1-hydroxybenzotriazole, 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / 1.) 30 min, room temperature, 2.) THF, 1 h, 0 deg C, 3.) 5 h, room temperature

5: 93 percent / TFA / CH₂Cl₂ / 0.5 h / Ambient temperature

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; dmap; triethylamine; In dichloromethane;
DOI:10.1021/jo00330a010

Reference yield:

: 78166-92-4
-D-seryl>-N-methyl-L-alanine 2,2,2-Trichloroethyl Ester

: 78186-12-6
-O-<-L-valyl>-D-seryl>-N-methyl-L-alanine 2,2,2-Trichloroethyl Ester

Guidance literature:: Multi-step reaction with 3 steps

1: 87.5 percent / 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / 4-(dimethylamino)pyridine / CH₂Cl₂ / 1.) 0 deg C, 3 h, 2.) room temperature, overnight

2: 1.)trifluoroacetic acid, 2.) 1-hydroxybenzotriazole, 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / 1.) 30 min, room temperature, 2.) THF, 1 h, 0 deg C, 3.) 5 h, room temperature

3: 93 percent / TFA / CH₂Cl₂ / 0.5 h / Ambient temperature

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; dmap; In dichloromethane;
DOI:10.1021/jo00330a010