tert-butyl (2S,5S,6S)-2-benzyloxymethyl-6-[(3R)-3-hydroxynonyl]-1-azaspiro[4.5]decane-1-carboxylate

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Chemical Name:tert-butyl (2S,5S,6S)-2-benzyloxymethyl-6-[(3R)-3-hydroxynonyl]-1-azaspiro[4.5]decane-1-carboxylate
CAS No.:844698-98-2
Molecular Formula:C₃₁H₅₁NO₄
Molecular Weight:501.75
Hs Code.:

Synonyms:tert-butyl (2S,5S,6S)-2-benzyloxymethyl-6-[(3R)-3-hydroxynonyl]-1-azaspiro[4.5]decane-1-carboxylate

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Chemical Property of tert-butyl (2S,5S,6S)-2-benzyloxymethyl-6-[(3R)-3-hydroxynonyl]-1-azaspiro[4.5]decane-1-carboxylate

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Technology Process of tert-butyl (2S,5S,6S)-2-benzyloxymethyl-6-[(3R)-3-hydroxynonyl]-1-azaspiro[4.5]decane-1-carboxylate

There total 6 articles about tert-butyl (2S,5S,6S)-2-benzyloxymethyl-6-[(3R)-3-hydroxynonyl]-1-azaspiro[4.5]decane-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 844699-02-1
tert-butyl (2S,5S,6S)-2-benzyloxymethyl-6-[(1E,3R)-3-hydroxynon-1-enyl]-1-azaspiro[4.5]decane-1-carboxylate

: 844698-98-2
tert-butyl (2S,5S,6S)-2-benzyloxymethyl-6-[(3R)-3-hydroxynonyl]-1-azaspiro[4.5]decane-1-carboxylate

Guidance literature:: With hydrogen; platinum(IV) oxide; In ethyl acetate; for 0.25h; under 760 Torr;
DOI:10.1021/ja040213e

Reference yield:

: 152500-21-5
(S)-5-benzyloxymetyl-1-tert-butoxycarbonyl-2-pyrrolidinone

: 844698-98-2
tert-butyl (2S,5S,6S)-2-benzyloxymethyl-6-[(3R)-3-hydroxynonyl]-1-azaspiro[4.5]decane-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 79 percent / tetrahydrofuran / 2 h / 0 °C

2: 88 percent / tetrahydrofuran; toluene / 2 h / 0 °C

3: aq. K₂CO₃ / methanol / 2 h / 20 °C

4: 81 percent / H₂ / PtO₂ / ethyl acetate / 0.25 h / 760 Torr

With hydrogen; potassium carbonate; platinum(IV) oxide; In tetrahydrofuran; methanol; ethyl acetate; toluene;
DOI:10.1021/ja040213e

Reference yield:

: 484061-45-2
tert-butyl (1S)-[(9E,11E)-1-benzyloxymethyl-4-oxo-9,11-octadecadienyl]carbamate

: 844698-98-2
tert-butyl (2S,5S,6S)-2-benzyloxymethyl-6-[(3R)-3-hydroxynonyl]-1-azaspiro[4.5]decane-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / tetrahydrofuran; toluene / 2 h / 0 °C

2: aq. K₂CO₃ / methanol / 2 h / 20 °C

3: 81 percent / H₂ / PtO₂ / ethyl acetate / 0.25 h / 760 Torr

With hydrogen; potassium carbonate; platinum(IV) oxide; In tetrahydrofuran; methanol; ethyl acetate; toluene;
DOI:10.1021/ja040213e