Mometasone Furoate Impurity A

Base Information

Chemical Name:Mometasone Furoate Impurity A
CAS No.:83880-65-3
Molecular Formula:C27H29 Cl O5
Molecular Weight:468.977
Hs Code.:
UNII:M2A68F897F
Mol file:83880-65-3.mol

Synonyms:83880-65-3;Mometasone Furoate Impurity A;M2A68F897F;UNII-M2A68F897F;Mometasone furoate impurity A [EP];21-chloro-16alpha-methyl-3,20-dioxopregna-1,4,9(11)-trien-17-yl furan-2-carboxylate;[(8S,10S,13S,14S,16R,17R)-17-(2-Chloroacetyl)-10,13,16-trimethyl-3-oxo-7,8,12,14,15,16-hexahydro-6H-cyclopenta[a]phenanthren-17-yl] furan-2-carboxylate;(16alpha)-21-Chloro-17-((2-furanylcarbonyl)oxy)-16-methylpregna-1,4,9(11)-triene-3,20-dione;Pregna-1,4,9(11)-triene-3,20-dione, 21-chloro-17-((2-furanylcarbonyl)oxy)-16-methyl-, (16alpha)-;MOMETASONE FUROATE IMPURITY A [EP IMPURITY];(16.ALPHA.)-21-CHLORO-17-((2-FURANYLCARBONYL)OXY)-16-METHYLPREGNA-1,4,9(11)-TRIENE-3,20-DIONE;21-CHLORO-16.ALPHA.-METHYL-3,20-DIOXOPREGNA-1,4,9(11)-TRIEN-17-YL FURAN-2-CARBOXYLATE;PREGNA-1,4,9(11)-TRIENE-3,20-DIONE, 21-CHLORO-17-((2-FURANYLCARBONYL)OXY)-16-METHYL-, (16.ALPHA.)-

Suppliers and Price of Mometasone Furoate Impurity A

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
MometasoneFuroateImpurityA
100mg
$ 3575.00

Medical Isotopes, Inc.
MometasoneFuroateImpurityA
2.5 mg
$ 675.00

Total 15 raw suppliers

Chemical Property of Mometasone Furoate Impurity A

Chemical Property:

PSA：73.58000
LogP:5.45710
Storage Temp.:-20°C Freezer
Solubility.:Chloroform (Slightly), DMSO (Slightly), Methanol (Very Slightly, Sonicated)
XLogP3:5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:468.1703517
Heavy Atom Count:33
Complexity:995

Purity/Quality:

99% ^*data from raw suppliers

MometasoneFuroateImpurityA ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1CC2C3CCC4=CC(=O)C=CC4(C3=CCC2(C1(C(=O)CCl)OC(=O)C5=CC=CO5)C)C
Isomeric SMILES:C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4(C3=CC[C@@]2([C@]1(C(=O)CCl)OC(=O)C5=CC=CO5)C)C
Uses Mometasone Furoate Impurity A is a topical corticosteroid used as an anti-inflammatory. Mometasone Furoate Impurity A (Mometasone EP Impurity A) is an impurity of Mometasone Furoate, a topical corticosteroid used as an anti-inflammatory.

Technology Process of Mometasone Furoate Impurity A

There total 10 articles about Mometasone Furoate Impurity A which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 898-84-0,96893-16-2,7801-18-5
11α-hydroxy-androsta-1,4-diene-3,17-dione

: 83880-65-3
21-chloro-16α-methyl-17α-hydroxy-1,4,9(11)-pregnatriene-3,20-dione 17-(2'-furoate)

Guidance literature:: Multi-step reaction with 5 steps

1.1: phosphorus pentachloride / tetrahydrofuran / 3 h / -60 - -50 °C / Inert atmosphere

1.2: 3 h / 0 - 25 °C / Inert atmosphere

1.3: 10 h / 0 - 40 °C / Inert atmosphere

2.1: sodium carbonate / methanol; water / 10 h / 20 - 30 °C

3.1: 1H-imidazole / dichloromethane / 3 h / 0 - 10 °C / Inert atmosphere

4.1: n-butyllithium / tetrahydrofuran / 2 h / -60 - -50 °C / Inert atmosphere

4.2: 0.5 h / 20 °C

5.1: triethylamine / dichloromethane / 10.5 h / -5 - 10 °C / Inert atmosphere

With 1H-imidazole; n-butyllithium; phosphorus pentachloride; sodium carbonate; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water;