phenylmethyl 3-(4-{[4-[5-fluoro-2-(methyloxy)phenyl]-2-hydroxy-4-methyl-2-(trifluoromethyl)pentyl]amino}-6-methyl-1H-indazol-1-yl)benzoate

Base Information

Chemical Name:phenylmethyl 3-(4-{[4-[5-fluoro-2-(methyloxy)phenyl]-2-hydroxy-4-methyl-2-(trifluoromethyl)pentyl]amino}-6-methyl-1H-indazol-1-yl)benzoate
CAS No.:913003-17-5
Molecular Formula:C₃₆H₃₅F₄N₃O₄
Molecular Weight:649.685
Hs Code.:

Synonyms:phenylmethyl 3-(4-{[4-[5-fluoro-2-(methyloxy)phenyl]-2-hydroxy-4-methyl-2-(trifluoromethyl)pentyl]amino}-6-methyl-1H-indazol-1-yl)benzoate

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Chemical Property of phenylmethyl 3-(4-{[4-[5-fluoro-2-(methyloxy)phenyl]-2-hydroxy-4-methyl-2-(trifluoromethyl)pentyl]amino}-6-methyl-1H-indazol-1-yl)benzoate

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Technology Process of phenylmethyl 3-(4-{[4-[5-fluoro-2-(methyloxy)phenyl]-2-hydroxy-4-methyl-2-(trifluoromethyl)pentyl]amino}-6-methyl-1H-indazol-1-yl)benzoate

There total 3 articles about phenylmethyl 3-(4-{[4-[5-fluoro-2-(methyloxy)phenyl]-2-hydroxy-4-methyl-2-(trifluoromethyl)pentyl]amino}-6-methyl-1H-indazol-1-yl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 271587-47-4
2-[2-(5-fluoro-2-methoxyphenyl)-2-methylpropyl]-2-(trifluoromethyl)oxirane

: 913003-15-3
phenylmethyl 3-(4-amino-6-methyl-1H-indazol-1-yl)benzoate

: 913003-17-5
phenylmethyl 3-(4-{[4-[5-fluoro-2-(methyloxy)phenyl]-2-hydroxy-4-methyl-2-(trifluoromethyl)pentyl]amino}-6-methyl-1H-indazol-1-yl)benzoate

Guidance literature:: ytterbium(III) triflate; In acetonitrile; at 85 - 100 ℃; for 39h;

Reference yield:

: 913003-16-4
6-methyl-1H-indazol-4-amine hydrochloride

: 913003-17-5
phenylmethyl 3-(4-{[4-[5-fluoro-2-(methyloxy)phenyl]-2-hydroxy-4-methyl-2-(trifluoromethyl)pentyl]amino}-6-methyl-1H-indazol-1-yl)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide; potassium carbonate / N,N-dimethyl-formamide / Heating / reflux

2: ytterbium(III) triflate / acetonitrile / 39 h / 85 °C / Heating / reflux

With trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide; potassium carbonate; ytterbium(III) triflate; In N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 437604-16-5
3-iodobenzoic acid benzyl ester

: 913003-17-5
phenylmethyl 3-(4-{[4-[5-fluoro-2-(methyloxy)phenyl]-2-hydroxy-4-methyl-2-(trifluoromethyl)pentyl]amino}-6-methyl-1H-indazol-1-yl)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide; potassium carbonate / N,N-dimethyl-formamide / Heating / reflux

2: ytterbium(III) triflate / acetonitrile / 39 h / 85 °C / Heating / reflux

With trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide; potassium carbonate; ytterbium(III) triflate; In N,N-dimethyl-formamide; acetonitrile;