L-Ile-D-Pip-L-Pip-D-(N-Me)Phe

Base Information

Chemical Name:L-Ile-D-Pip-L-Pip-D-(N-Me)Phe
CAS No.:138775-25-4
Molecular Formula:C₂₈H₄₂N₄O₅
Molecular Weight:514.665
Hs Code.:

Synonyms:L-Ile-D-Pip-L-Pip-D-(N-Me)Phe

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of L-Ile-D-Pip-L-Pip-D-(N-Me)Phe

Chemical Property:

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Technology Process of L-Ile-D-Pip-L-Pip-D-(N-Me)Phe

There total 8 articles about L-Ile-D-Pip-L-Pip-D-(N-Me)Phe which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: L-Ile-D-Pip-L-Pip-D-(N-Me)Phe-OCH₂Ph

: 138775-25-4
L-Ile-D-Pip-L-Pip-D-(N-Me)Phe

Guidance literature:: With hydrogen; palladium dihydroxide; In methanol; for 16h; under 2844.3 Torr;
DOI:10.1021/jm00099a019

Reference yield:

: 150521-32-7,132910-78-2
(S)-1-N-Boc-piperidine-2-al

: 138775-25-4
L-Ile-D-Pip-L-Pip-D-(N-Me)Phe

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) N,N-diisopropylethylamine (DIEA), bis(2-oxo-3-oxazolidinyl)phosphinic chloride (BOP-Cl), 2.) N,N-diisopropylethylamine (DIEA) / 1.) CH₂Cl₂, 1.5 h, 2.) CH₂Cl₂, 0 deg C, 16 h

2: HCl (gas) / ethyl acetate

3: 92 percent / N,N-diisopropylethylamine (DIEA) / CH₂Cl₂ / 2 h / pH 8

4: diethylamine / acetonitrile / Ambient temperature

5: 82 percent / AgCN / toluene / 0.5 h / 80 - 85 °C

6: diethylamine / acetonitrile / Ambient temperature

7: H₂ / 20percent Pd(OH)2/C / methanol / 16 h / 2844.3 Torr

With hydrogenchloride; silver cyanide; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; diethylamine; N-ethyl-N,N-diisopropylamine; palladium dihydroxide; In methanol; dichloromethane; ethyl acetate; toluene; acetonitrile;
DOI:10.1021/jm00099a019

Reference yield:

: H-D-(N-Me)Phe-OCH₂Ph

: 138775-25-4
L-Ile-D-Pip-L-Pip-D-(N-Me)Phe

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) N,N-diisopropylethylamine (DIEA), bis(2-oxo-3-oxazolidinyl)phosphinic chloride (BOP-Cl), 2.) N,N-diisopropylethylamine (DIEA) / 1.) CH₂Cl₂, 1.5 h, 2.) CH₂Cl₂, 0 deg C, 16 h

2: HCl (gas) / ethyl acetate

3: 92 percent / N,N-diisopropylethylamine (DIEA) / CH₂Cl₂ / 2 h / pH 8

4: diethylamine / acetonitrile / Ambient temperature

5: 82 percent / AgCN / toluene / 0.5 h / 80 - 85 °C

6: diethylamine / acetonitrile / Ambient temperature

7: H₂ / 20percent Pd(OH)2/C / methanol / 16 h / 2844.3 Torr

With hydrogenchloride; silver cyanide; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; diethylamine; N-ethyl-N,N-diisopropylamine; palladium dihydroxide; In methanol; dichloromethane; ethyl acetate; toluene; acetonitrile;
DOI:10.1021/jm00099a019