dibenzyl {4-[(benzyloxy)amino]-1-(3,4-difluorophenyl)-4-oxobutyl}phosphonate

Base Information

• Chemical Name: dibenzyl {4-[(benzyloxy)amino]-1-(3,4-difluorophenyl)-4-oxobutyl}phosphonate
• CAS No.: 1332895-40-5
• Molecular Formula: C₃₁H₃₀F₂NO₅P
• Molecular Weight: 565.553
• Mol file: 1332895-40-5.mol

Synonyms:dibenzyl {4-[(benzyloxy)amino]-1-(3,4-difluorophenyl)-4-oxobutyl}phosphonate

Chemical Property of dibenzyl {4-[(benzyloxy)amino]-1-(3,4-difluorophenyl)-4-oxobutyl}phosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dibenzyl {4-[(benzyloxy)amino]-1-(3,4-difluorophenyl)-4-oxobutyl}phosphonate

There total 5 articles about dibenzyl {4-[(benzyloxy)amino]-1-(3,4-difluorophenyl)-4-oxobutyl}phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

diethyl {4-[(benzyloxy)amino]-1-(3,4-difluorophenyl)-4-oxobutyl}phosphonate (1332895-33-6) + O-benzyl-N,N'-dicyclohexylisourea (6738-17-6) → dibenzyl {4-[(benzyloxy)amino]-1-(3,4-difluorophenyl)-4-oxobutyl}phosphonate (1332895-40-5)

Guidance literature:

diethyl {4-[(benzyloxy)amino]-1-(3,4-difluorophenyl)-4-oxobutyl}phosphonate; With trimethylsilyl bromide; In dichloromethane; at 0 - 20 ℃; for 24h;

With water; In tetrahydrofuran; at 20 ℃;

O-benzyl-N,N'-dicyclohexylisourea; In benzene; at 80 ℃;

DOI:10.1021/jm200694q

Reference yield:

4-(diethoxyphosphoryl)-4-(3,4-difluorophenyl)butanoic acid (1332895-30-3) → dibenzyl {4-[(benzyloxy)amino]-1-(3,4-difluorophenyl)-4-oxobutyl}phosphonate (1332895-40-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 1,1'-carbonyldiimidazole / dichloromethane / 0.75 h / 20 °C

1.2: 20 °C

2.1: trimethylsilyl bromide / dichloromethane / 24 h / 0 - 20 °C

2.2: 20 °C

2.3: 80 °C

With trimethylsilyl bromide; 1,1'-carbonyldiimidazole; In dichloromethane;

DOI:10.1021/jm200694q

Reference yield:

diethyl [1-(3,4-difluorophenyl)-4-oxobutyl]phosphonate (1332895-27-8) → dibenzyl {4-[(benzyloxy)amino]-1-(3,4-difluorophenyl)-4-oxobutyl}phosphonate (1332895-40-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: selenium(IV) oxide; dihydrogen peroxide / tetrahydrofuran / 4 h / 65 °C

2.1: 1,1'-carbonyldiimidazole / dichloromethane / 0.75 h / 20 °C

2.2: 20 °C

3.1: trimethylsilyl bromide / dichloromethane / 24 h / 0 - 20 °C

3.2: 20 °C

3.3: 80 °C

With selenium(IV) oxide; trimethylsilyl bromide; dihydrogen peroxide; 1,1'-carbonyldiimidazole; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm200694q

upstream raw materials:

diethyl [1-(3,4-difluorophenyl)-4-oxobutyl]phosphonate

4-(diethoxyphosphoryl)-4-(3,4-difluorophenyl)butanoic acid

diethyl {4-[(benzyloxy)amino]-1-(3,4-difluorophenyl)-4-oxobutyl}phosphonate

O-benzyl-N,N'-dicyclohexylisourea

Downstream raw materials:

[1-(3,4-difluorophenyl)-4-(hydroxyamino)-4-oxobutyl]phosphonic acid