N⁴-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-[[(triisopropylsilyl)oxy]methyl]-6-¹³C-cytidine

Base Information

• Chemical Name: N⁴-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-[[(triisopropylsilyl)oxy]methyl]-6-¹³C-cytidine
• CAS No.: 1373621-16-9
• Molecular Formula: C₄₂H₅₅N₃O₉Si
• Molecular Weight: 774.988

Synonyms:N⁴-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-[[(triisopropylsilyl)oxy]methyl]-6-¹³C-cytidine

Chemical Property of N⁴-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-[[(triisopropylsilyl)oxy]methyl]-6-¹³C-cytidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N⁴-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-[[(triisopropylsilyl)oxy]methyl]-6-¹³C-cytidine

There total 7 articles about N⁴-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-[[(triisopropylsilyl)oxy]methyl]-6-¹³C-cytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

5'-O-(4,4'-dimethoxytrityl)-2'-O-[[(triisopropylsilyl)oxy]methyl]-6-13C-cytidine (1373621-14-7) + acetic anhydride (108-24-7) → N4-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-[[(triisopropylsilyl)oxy]methyl]-6-13C-cytidine (1373621-16-9)

Guidance literature:

In N,N-dimethyl-formamide; at 20 ℃; for 22h; Inert atmosphere;

DOI:10.1021/ja302148g

Reference yield:

C56(13)CH76N2O12SSi → N4-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-[[(triisopropylsilyl)oxy]methyl]-6-13C-cytidine (1373621-16-9)

Guidance literature:

With ammonia; In tetrahydrofuran; water; at 20 ℃; for 18h; Inert atmosphere;

DOI:10.1021/ja302148g

Reference yield:

5'-O-(4,4'-dimethoxytrityl)-2'-O-[[(triisopropylsilyl)oxy]methyl]-6-13C-uridine (1373621-10-3) → N4-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-[[(triisopropylsilyl)oxy]methyl]-6-13C-cytidine (1373621-16-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: pyridine; dmap / 2 h / 0 - 20 °C / Inert atmosphere

2.1: dmap; triethylamine / dichloromethane / 0.17 h / Inert atmosphere

2.2: 4 h / Inert atmosphere

3.1: ammonia / tetrahydrofuran; water / 18 h / 20 °C / Inert atmosphere

With pyridine; dmap; ammonia; triethylamine; In tetrahydrofuran; dichloromethane; water;

DOI:10.1021/ja302148g

upstream raw materials:

5'-O-(4,4'-dimethoxytrityl)-2'-O-[[(triisopropylsilyl)oxy]methyl]-6-¹³C-uridine

3'-O-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-[[(triisopropylsilyl)oxy]methyl]-6-¹³C-uridine

5'-O-(4,4'-dimethoxytrityl)-2'-O-[[(triisopropylsilyl)oxy]methyl]-6-¹³C-cytidine

acetic anhydride

Downstream raw materials:

5'-O-(4,4'-dimethoxytrityl)-2'-O-[[(triisopropylsilyl)oxy]methyl]-6-¹³C-cytidine

N⁴-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-[[(triisopropylsilyl)oxy]methyl]-6-¹³C-cytidine 3'-O-(2'-cyanoethyl N,N-diisopropylphoshphoramidite)

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1373621-16-9 N⁴-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-[[(triisopropylsilyl)oxy]methyl]-6-¹³C-cytidine

Send

Send

Metric Ton KG G Pound L ML

Send

Send