(1R,2R,3S,5R)-2-(benzyloxy)-2,6,6-trimethylbicyclo[3.1.1]heptan-3-yl 3,3,3-trifluoropropanoate

Base Information

Chemical Name:(1R,2R,3S,5R)-2-(benzyloxy)-2,6,6-trimethylbicyclo[3.1.1]heptan-3-yl 3,3,3-trifluoropropanoate
CAS No.:1338323-39-9
Molecular Formula:C₂₀H₂₅F₃O₃
Molecular Weight:370.412
Hs Code.:

Synonyms:(1R,2R,3S,5R)-2-(benzyloxy)-2,6,6-trimethylbicyclo[3.1.1]heptan-3-yl 3,3,3-trifluoropropanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R,2R,3S,5R)-2-(benzyloxy)-2,6,6-trimethylbicyclo[3.1.1]heptan-3-yl 3,3,3-trifluoropropanoate

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Technology Process of (1R,2R,3S,5R)-2-(benzyloxy)-2,6,6-trimethylbicyclo[3.1.1]heptan-3-yl 3,3,3-trifluoropropanoate

There total 4 articles about (1R,2R,3S,5R)-2-(benzyloxy)-2,6,6-trimethylbicyclo[3.1.1]heptan-3-yl 3,3,3-trifluoropropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2516-99-6
3,3,3-Trifluoropropionic acid

: 1338323-34-4
(1R,2R,3S,5R)-2-(benzyloxy)-2,6,6-trimethylbicyclo[3.1.1]heptan-3-ol

: 1338323-39-9
(1R,2R,3S,5R)-2-(benzyloxy)-2,6,6-trimethylbicyclo[3.1.1]heptan-3-yl 3,3,3-trifluoropropanoate

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 20 ℃; for 12h; Inert atmosphere;
DOI:10.1016/j.tetlet.2011.08.034

Reference yield:

: 7785-26-4,25766-18-1
(-)-α-pinene

: 1338323-39-9
(1R,2R,3S,5R)-2-(benzyloxy)-2,6,6-trimethylbicyclo[3.1.1]heptan-3-yl 3,3,3-trifluoropropanoate

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine; osmium(VIII) oxide; 4-methylmorpholine N-oxide / Inert atmosphere

2: pyridinium p-toluenesulfonate / toluene / Reflux; Inert atmosphere

3: diisobutylaluminium hydride / dichloromethane / 24 h / -78 - 20 °C / Inert atmosphere

4: dmap; dicyclohexyl-carbodiimide / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere

With pyridine; dmap; osmium(VIII) oxide; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; 4-methylmorpholine N-oxide; dicyclohexyl-carbodiimide; In dichloromethane; toluene;
DOI:10.1016/j.tetlet.2011.08.034

Reference yield:

: (1R,2R,6S,8R)-2,9,9-Trimethyl-4-phenyl-3,5-dioxa-tricyclo[6.1.1.0^2,6]decane

: 1338323-39-9
(1R,2R,3S,5R)-2-(benzyloxy)-2,6,6-trimethylbicyclo[3.1.1]heptan-3-yl 3,3,3-trifluoropropanoate

Guidance literature:: Multi-step reaction with 2 steps

1: diisobutylaluminium hydride / dichloromethane / 24 h / -78 - 20 °C / Inert atmosphere

2: dmap; dicyclohexyl-carbodiimide / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere

With dmap; diisobutylaluminium hydride; dicyclohexyl-carbodiimide; In dichloromethane;
DOI:10.1016/j.tetlet.2011.08.034