N¹-[(2S,3R)-3-hydroxy-4-{[2-(3-methoxyphenyl)propan-2-yl]amino}-1-phenylbutan-2-yl]-N³,N³-dipropylisophthalamide

Base Information

• Chemical Name: N¹-[(2S,3R)-3-hydroxy-4-{[2-(3-methoxyphenyl)propan-2-yl]amino}-1-phenylbutan-2-yl]-N³,N³-dipropylisophthalamide
• CAS No.: 1422207-61-1
• Molecular Formula: C₃₄H₄₅N₃O₄
• Molecular Weight: 559.749

Synonyms:N¹-[(2S,3R)-3-hydroxy-4-{[2-(3-methoxyphenyl)propan-2-yl]amino}-1-phenylbutan-2-yl]-N³,N³-dipropylisophthalamide

Chemical Property of N¹-[(2S,3R)-3-hydroxy-4-{[2-(3-methoxyphenyl)propan-2-yl]amino}-1-phenylbutan-2-yl]-N³,N³-dipropylisophthalamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N¹-[(2S,3R)-3-hydroxy-4-{[2-(3-methoxyphenyl)propan-2-yl]amino}-1-phenylbutan-2-yl]-N³,N³-dipropylisophthalamide

There total 10 articles about N¹-[(2S,3R)-3-hydroxy-4-{[2-(3-methoxyphenyl)propan-2-yl]amino}-1-phenylbutan-2-yl]-N³,N³-dipropylisophthalamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

rac-N1-[(2S,3R)-3-hydroxy-4-{[2-(3-methoxyphenyl)propan-2-yl]amino}-1-phenylbutan-2-yl]-N3,N3-dipropylisophthalamide → N1-[(2S,3R)-3-hydroxy-4-{[2-(3-methoxyphenyl)propan-2-yl]amino}-1-phenylbutan-2-yl]-N3,N3-dipropylisophthalamide (1422207-61-1)

Guidance literature:

In chloroform; ethyl acetate; 2,2'-iminobis[ethanol]; Resolution of racemate; Inert atmosphere;

DOI:10.1016/j.ejmech.2018.11.068

Reference yield:

C20H28N2O2*ClH (1422208-55-6) + N,N-Dipropylisophthalamic acid (126926-35-0) → N1-[(2S,3R)-3-hydroxy-4-{[2-(3-methoxyphenyl)propan-2-yl]amino}-1-phenylbutan-2-yl]-N3,N3-dipropylisophthalamide (1422207-61-1)

Guidance literature:

With N-ethylmorpholine;; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1016/j.bmcl.2012.11.118

Reference yield:

{(1S,2R)-1-benzyl-2-hydroxy-3-[1-(3-methoxyphenyl)-1-methylethylamino]propyl}carbamic acid tert-butyl ester → N1-[(2S,3R)-3-hydroxy-4-{[2-(3-methoxyphenyl)propan-2-yl]amino}-1-phenylbutan-2-yl]-N3,N3-dipropylisophthalamide (1422207-61-1)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / 1,4-dioxane; dichloromethane / 16 h / 20 °C / Inert atmosphere

2: N-ethylmorpholine;; HATU / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

With N-ethylmorpholine;; hydrogenchloride; HATU; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2012.11.118

upstream raw materials:

1-(3-methoxyphenyl)-1-methylethylamine

C₂₀H₂₈N₂O₂*ClH

N,N-Dipropylisophthalamic acid

(1-oxiranyl-2-phenylethyl)carbamic acid tert-butyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1422207-61-1 N¹-[(2S,3R)-3-hydroxy-4-{[2-(3-methoxyphenyl)propan-2-yl]amino}-1-phenylbutan-2-yl]-N³,N³-dipropylisophthalamide

Send

Send

Metric Ton KG G Pound L ML

Send

Send