tert-butyl 2-(methylamino)-4-(3-nitrophenyl)-1H-imidazole-1-carboxylate

Base Information

Chemical Name:tert-butyl 2-(methylamino)-4-(3-nitrophenyl)-1H-imidazole-1-carboxylate
CAS No.:1574306-49-2
Molecular Formula:C₁₅H₁₈N₄O₄
Molecular Weight:318.332
Hs Code.:

Synonyms:tert-butyl 2-(methylamino)-4-(3-nitrophenyl)-1H-imidazole-1-carboxylate

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Chemical Property of tert-butyl 2-(methylamino)-4-(3-nitrophenyl)-1H-imidazole-1-carboxylate

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Technology Process of tert-butyl 2-(methylamino)-4-(3-nitrophenyl)-1H-imidazole-1-carboxylate

There total 3 articles about tert-butyl 2-(methylamino)-4-(3-nitrophenyl)-1H-imidazole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1574306-48-1
2-(methylamino)-4-(3-nitrophenyl)-1H-imidazolium bromide

: 1574306-49-2
tert-butyl 2-(methylamino)-4-(3-nitrophenyl)-1H-imidazole-1-carboxylate

Guidance literature:: 2-(methylamino)-4-(3-nitrophenyl)-1H-imidazolium bromide; With sodium hydroxide; In methanol; water; pH=9;

di-tert-butyl dicarbonate; In methanol; water; at 20 ℃; for 3h;
DOI:10.1016/j.ejmech.2013.12.034

Reference yield:

: 2227-64-7
3'-nitro-2-bromoacetophenone

: 1574306-49-2
tert-butyl 2-(methylamino)-4-(3-nitrophenyl)-1H-imidazole-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: dmap / acetonitrile / 15 h / 50 °C

2.1: hydrazine hydrate / ethanol / 0.67 h / 120 °C / Microwave irradiation

3.1: sodium hydroxide / methanol; water / pH 9

3.2: 3 h / 20 °C

With dmap; hydrazine hydrate; sodium hydroxide; In methanol; ethanol; water; acetonitrile;
DOI:10.1016/j.ejmech.2013.12.034

Reference yield:

: 1040373-81-6
2-hydroxy-1-methyl-2-(3-nitrophenyl)-2,3-dihydro-1H-imidazo[1,2-a]pyrimidin-4-ium bromide

: 1574306-49-2
tert-butyl 2-(methylamino)-4-(3-nitrophenyl)-1H-imidazole-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrazine hydrate / ethanol / 0.67 h / 120 °C / Microwave irradiation

2.1: sodium hydroxide / methanol; water / pH 9

2.2: 3 h / 20 °C

With hydrazine hydrate; sodium hydroxide; In methanol; ethanol; water;
DOI:10.1016/j.ejmech.2013.12.034