N-[2-(1,3-dioxolan-2-yl)-1-methylimidazol-4-yl]-2-acetamido-3-phenylpropanamide

Base Information

Chemical Name:N-[2-(1,3-dioxolan-2-yl)-1-methylimidazol-4-yl]-2-acetamido-3-phenylpropanamide
CAS No.:1333113-62-4
Molecular Formula:C₁₈H₂₂N₄O₄
Molecular Weight:358.397
Hs Code.:

Synonyms:N-[2-(1,3-dioxolan-2-yl)-1-methylimidazol-4-yl]-2-acetamido-3-phenylpropanamide

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Chemical Property of N-[2-(1,3-dioxolan-2-yl)-1-methylimidazol-4-yl]-2-acetamido-3-phenylpropanamide

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Technology Process of N-[2-(1,3-dioxolan-2-yl)-1-methylimidazol-4-yl]-2-acetamido-3-phenylpropanamide

There total 4 articles about N-[2-(1,3-dioxolan-2-yl)-1-methylimidazol-4-yl]-2-acetamido-3-phenylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1333113-54-4
2-(1,3-dioxolan-2-yl)-1-methylimidazol-4-amine

: 2901-75-9
(R,S)-N-acetyl phenylalanine

: 1333113-62-4
N-[2-(1,3-dioxolan-2-yl)-1-methylimidazol-4-yl]-2-acetamido-3-phenylpropanamide

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 22h;
DOI:10.1016/j.tetlet.2011.07.025

Reference yield:

: 73455-94-4
1-methyl-4-nitro-1H-imidazol-2-carbaldehyde

: 1333113-62-4
N-[2-(1,3-dioxolan-2-yl)-1-methylimidazol-4-yl]-2-acetamido-3-phenylpropanamide

Guidance literature:: Multi-step reaction with 3 steps

1: toluene-4-sulfonic acid / toluene / 6 h / Reflux

2: palladium 10% on activated carbon; hydrogen / 1,4-dioxane / 24 h / 760.05 Torr

3: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 22 h / 20 °C

With palladium 10% on activated carbon; hydrogen; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.tetlet.2011.07.025

Reference yield:

: 1333113-52-2
2-(1,3-dioxolan-2-yl)-1-methyl-4-nitroimidazole

: 1333113-62-4
N-[2-(1,3-dioxolan-2-yl)-1-methylimidazol-4-yl]-2-acetamido-3-phenylpropanamide

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / 1,4-dioxane / 24 h / 760.05 Torr

2: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 22 h / 20 °C

With palladium 10% on activated carbon; hydrogen; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2011.07.025