Technology Process of (3aS,8aR)-1-benzyl-4-bromo-8-methyl-3a-phenyl-3,3a,8,8a-tetrahydropyrrolo[2,3-b]indol-2(1H)-one
There total 5 articles about (3aS,8aR)-1-benzyl-4-bromo-8-methyl-3a-phenyl-3,3a,8,8a-tetrahydropyrrolo[2,3-b]indol-2(1H)-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
copper (I) trifluoromethane sulfonate toluene complex; sodium hydrogencarbonate; (S,S)-2,2'-isopropylidenebis(4-phenyl-2-oxazoline);
In
dichloromethane;
at -20 ℃;
for 12h;
optical yield given as %ee;
enantioselective reaction;
Inert atmosphere;
DOI:10.1021/ja305100g
- Guidance literature:
-
Multi-step reaction with 2 steps
1: tetrabutylammonium sulfate; potassium hydroxide / dichloromethane; water
2: copper (I) trifluoromethane sulfonate toluene complex; sodium hydrogencarbonate; (S,S)-2,2'-isopropylidenebis(4-phenyl-2-oxazoline) / dichloromethane / 12 h / -20 °C / Inert atmosphere
With
copper (I) trifluoromethane sulfonate toluene complex; sodium hydrogencarbonate; (S,S)-2,2'-isopropylidenebis(4-phenyl-2-oxazoline); tetrabutylammonium sulfate; potassium hydroxide;
In
dichloromethane; water;
DOI:10.1021/ja305100g
- Guidance literature:
-
Multi-step reaction with 5 steps
1: diethyl ether
2: sodium acetate; hydrazine hydrate / ethyl methyl ether
3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C
4: tetrabutylammonium sulfate; potassium hydroxide / dichloromethane; water
5: copper (I) trifluoromethane sulfonate toluene complex; sodium hydrogencarbonate; (S,S)-2,2'-isopropylidenebis(4-phenyl-2-oxazoline) / dichloromethane / 12 h / -20 °C / Inert atmosphere
With
copper (I) trifluoromethane sulfonate toluene complex; sodium acetate; sodium hydrogencarbonate; (S,S)-2,2'-isopropylidenebis(4-phenyl-2-oxazoline); hydrazine hydrate; tetrabutylammonium sulfate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; potassium hydroxide;
In
diethyl ether; ethyl methyl ether; dichloromethane; water;
DOI:10.1021/ja305100g
