2-(4-fluorophenyl)thiazole-4-carboxylic acid [1-(8-methylpyrrolo[1,2-a]pyrazin-1-yl)pyrrolidin-3-yl]amide

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Chemical Name:2-(4-fluorophenyl)thiazole-4-carboxylic acid [1-(8-methylpyrrolo[1,2-a]pyrazin-1-yl)pyrrolidin-3-yl]amide
CAS No.:1613022-88-0
Molecular Formula:C₂₂H₂₀FN₅OS
Molecular Weight:421.498
Hs Code.:

Synonyms:2-(4-fluorophenyl)thiazole-4-carboxylic acid [1-(8-methylpyrrolo[1,2-a]pyrazin-1-yl)pyrrolidin-3-yl]amide

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Chemical Property of 2-(4-fluorophenyl)thiazole-4-carboxylic acid [1-(8-methylpyrrolo[1,2-a]pyrazin-1-yl)pyrrolidin-3-yl]amide

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Technology Process of 2-(4-fluorophenyl)thiazole-4-carboxylic acid [1-(8-methylpyrrolo[1,2-a]pyrazin-1-yl)pyrrolidin-3-yl]amide

There total 8 articles about 2-(4-fluorophenyl)thiazole-4-carboxylic acid [1-(8-methylpyrrolo[1,2-a]pyrazin-1-yl)pyrrolidin-3-yl]amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (3S)-1-(8-methylpyrrolo[1,2-a]pyrazin-1-yl)pyrrolidin-3-amine dihydrochloride

: 863668-07-9
2-(4-fluorophenyl)-1,3-thiazole-4-carboxylic acid

: 1613022-88-0
2-(4-fluorophenyl)thiazole-4-carboxylic acid [1-(8-methylpyrrolo[1,2-a]pyrazin-1-yl)pyrrolidin-3-yl]amide

Guidance literature:: With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; dimethyl sulfoxide; for 0.5h;

Reference yield:

: 3284-47-7
ethyl 3-methyl-1H-pyrrole-2-carboxylate

: 1613022-88-0
2-(4-fluorophenyl)thiazole-4-carboxylic acid [1-(8-methylpyrrolo[1,2-a]pyrazin-1-yl)pyrrolidin-3-yl]amide

Guidance literature:: Multi-step reaction with 8 steps

1: sodium hydride / 1-methyl-pyrrolidin-2-one; mineral oil / 5 h / 130 °C

2: lithium hydroxide monohydrate / water; ethanol / 8 h / 75 °C

3: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; ammonia / 1,4-dioxane; 1-methyl-pyrrolidin-2-one / 20 °C

4: acetic acid / 4 h / 105 °C

5: trichlorophosphate / 20 - 35 °C

6: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 1 h / 120 °C

7: hydrogenchloride / 1,4-dioxane / 1 h / 60 °C

8: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / dimethyl sulfoxide; dichloromethane / 0.5 h

With hydrogenchloride; lithium hydroxide monohydrate; ammonia; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; trichlorophosphate; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane; water; acetic acid; dimethyl sulfoxide; mineral oil;

Reference yield:

: 1613022-99-3
ethyl 1-(2,2-diethoxyethyl)-3-methyl-1H-pyrrole-2-carboxylate

: 1613022-88-0
2-(4-fluorophenyl)thiazole-4-carboxylic acid [1-(8-methylpyrrolo[1,2-a]pyrazin-1-yl)pyrrolidin-3-yl]amide

Guidance literature:: Multi-step reaction with 7 steps

1: lithium hydroxide monohydrate / water; ethanol / 8 h / 75 °C

2: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; ammonia / 1,4-dioxane; 1-methyl-pyrrolidin-2-one / 20 °C

3: acetic acid / 4 h / 105 °C

4: trichlorophosphate / 20 - 35 °C

5: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 1 h / 120 °C

6: hydrogenchloride / 1,4-dioxane / 1 h / 60 °C

7: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / dimethyl sulfoxide; dichloromethane / 0.5 h

With hydrogenchloride; lithium hydroxide monohydrate; ammonia; triethylamine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; trichlorophosphate; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane; water; acetic acid; dimethyl sulfoxide;