N-[5-[(3,5-difluorophenyl)methyl]-1H-indazol-3-yl]-4-(4-methylpiperazin-1-yl)-2-(2,2,2-trifluoro-N-(tetrahydro-2H-pyran-4-yl)acetamido)benzamide

Base Information

Chemical Name:N-[5-[(3,5-difluorophenyl)methyl]-1H-indazol-3-yl]-4-(4-methylpiperazin-1-yl)-2-(2,2,2-trifluoro-N-(tetrahydro-2H-pyran-4-yl)acetamido)benzamide
CAS No.:1108745-38-5
Molecular Formula:C₃₃H₃₃F₅N₆O₃
Molecular Weight:656.655
Hs Code.:

Synonyms:N-[5-[(3,5-difluorophenyl)methyl]-1H-indazol-3-yl]-4-(4-methylpiperazin-1-yl)-2-(2,2,2-trifluoro-N-(tetrahydro-2H-pyran-4-yl)acetamido)benzamide

Suppliers and Price of N-[5-[(3,5-difluorophenyl)methyl]-1H-indazol-3-yl]-4-(4-methylpiperazin-1-yl)-2-(2,2,2-trifluoro-N-(tetrahydro-2H-pyran-4-yl)acetamido)benzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[5-[(3,5-difluorophenyl)methyl]-1H-indazol-3-yl]-4-(4-methylpiperazin-1-yl)-2-(2,2,2-trifluoro-N-(tetrahydro-2H-pyran-4-yl)acetamido)benzamide

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of N-[5-[(3,5-difluorophenyl)methyl]-1H-indazol-3-yl]-4-(4-methylpiperazin-1-yl)-2-(2,2,2-trifluoro-N-(tetrahydro-2H-pyran-4-yl)acetamido)benzamide

There total 17 articles about N-[5-[(3,5-difluorophenyl)methyl]-1H-indazol-3-yl]-4-(4-methylpiperazin-1-yl)-2-(2,2,2-trifluoro-N-(tetrahydro-2H-pyran-4-yl)acetamido)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.5%

: 1034976-52-7
4-(4-methylpiperazin-1-yl)-2-[(tetrahydropyran-4-yl)-(2,2,2-trifluoroacetyl)amino]benzoyl chloride

: 1108745-30-7
5-(3,5-difluoro-benzyl)-1H-indazol-3-ylamine

: 1108745-38-5
N-[5-[(3,5-difluorophenyl)methyl]-1H-indazol-3-yl]-4-(4-methylpiperazin-1-yl)-2-(2,2,2-trifluoro-N-(tetrahydro-2H-pyran-4-yl)acetamido)benzamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

Reference yield:

: 1034975-62-6
4-(4-methylpiperazine-1-yl)-2-(2,2,2-trifluoro-N-(tetrahydro-2H-pyran-4-yl)acetamido)benzoic acid trifluoroacetic acid salt

: 1108745-37-4
5-[1-(3,5-difluoro-phenyl)-ethyl]-1H-indazol-3-ylamine

: 1108745-38-5
N-[5-[(3,5-difluorophenyl)methyl]-1H-indazol-3-yl]-4-(4-methylpiperazin-1-yl)-2-(2,2,2-trifluoro-N-(tetrahydro-2H-pyran-4-yl)acetamido)benzamide

Guidance literature:: 4-(4-carboxy-3-(2,2,2-trifluoro-N-(tetrahydropyran-4-yl)acetamido)phenyl)-1-methylpiperazin-1-ium 2,2,2-trifluoroacetate; With oxalyl dichloride; N,N-dimethyl-formamide; at 20 ℃; for 2h;

5-[1-(3,5-difluoro-phenyl)-ethyl]-1H-indazol-3-ylamine; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at -20 ℃; for 4h;

Reference yield:

: 1034975-62-6
4-(4-methylpiperazine-1-yl)-2-(2,2,2-trifluoro-N-(tetrahydro-2H-pyran-4-yl)acetamido)benzoic acid trifluoroacetic acid salt

: 1108745-38-5
N-[5-[(3,5-difluorophenyl)methyl]-1H-indazol-3-yl]-4-(4-methylpiperazin-1-yl)-2-(2,2,2-trifluoro-N-(tetrahydro-2H-pyran-4-yl)acetamido)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 1.5 h / Large scale

2: pyridine / -40 - -30 °C / Large scale

With oxalyl dichloride; In pyridine; dichloromethane; N,N-dimethyl-formamide;