isopropyl 2-cyano-6-hydroxymethyl-3-methoxycarbonyl-4-(3-nitrophenyl)pyridine-5-carboxylate

Base Information

Chemical Name:isopropyl 2-cyano-6-hydroxymethyl-3-methoxycarbonyl-4-(3-nitrophenyl)pyridine-5-carboxylate
CAS No.:145220-87-7
Molecular Formula:C₁₉H₁₇N₃O₇
Molecular Weight:399.36
Hs Code.:

Synonyms:isopropyl 2-cyano-6-hydroxymethyl-3-methoxycarbonyl-4-(3-nitrophenyl)pyridine-5-carboxylate

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Chemical Property of isopropyl 2-cyano-6-hydroxymethyl-3-methoxycarbonyl-4-(3-nitrophenyl)pyridine-5-carboxylate

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Technology Process of isopropyl 2-cyano-6-hydroxymethyl-3-methoxycarbonyl-4-(3-nitrophenyl)pyridine-5-carboxylate

There total 6 articles about isopropyl 2-cyano-6-hydroxymethyl-3-methoxycarbonyl-4-(3-nitrophenyl)pyridine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 144686-67-9
isopropyl 4-acetoxyacetoacetate

: 145220-87-7
isopropyl 2-cyano-6-hydroxymethyl-3-methoxycarbonyl-4-(3-nitrophenyl)pyridine-5-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: morpholine, AcOH / benzene / Heating

2: 2.) AcOH / benzene / 1.) 80 deg C, 0.5 h, 2.) reflux, 2 h

3: 90 percent / HCO₂H / 5 h / Ambient temperature

4: NH₂OH*HCl, NaOAc / acetic acid / 0.75 h / Ambient temperature

5: Ac₂O / acetic acid / 1.) RT, 1 h, 2.) 100-105 deg C, 3 h, 3.) 115-120 deg C, 4.5 h

6: 95.4 percent / concd aq. NH₃ / methanol; CHCl₃ / 3 h

7: 39.3 percent / aq. HNO₃, AcOH / 1.5 h / Ambient temperature

With morpholine; ammonium hydroxide; formic acid; hydroxylamine hydrochloride; nitric acid; sodium acetate; acetic anhydride; acetic acid; In methanol; chloroform; acetic acid; benzene;
DOI:10.1248/cpb.40.1799

Reference yield:

: 4-Acetoxy-2-[1-(3-nitro-phenyl)-meth-(Z)-ylidene]-3-oxo-butyric acid isopropyl ester

: 145220-87-7
isopropyl 2-cyano-6-hydroxymethyl-3-methoxycarbonyl-4-(3-nitrophenyl)pyridine-5-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: 2.) AcOH / benzene / 1.) 80 deg C, 0.5 h, 2.) reflux, 2 h

2: 90 percent / HCO₂H / 5 h / Ambient temperature

3: NH₂OH*HCl, NaOAc / acetic acid / 0.75 h / Ambient temperature

4: Ac₂O / acetic acid / 1.) RT, 1 h, 2.) 100-105 deg C, 3 h, 3.) 115-120 deg C, 4.5 h

5: 95.4 percent / concd aq. NH₃ / methanol; CHCl₃ / 3 h

6: 39.3 percent / aq. HNO₃, AcOH / 1.5 h / Ambient temperature

With ammonium hydroxide; formic acid; hydroxylamine hydrochloride; nitric acid; sodium acetate; acetic anhydride; acetic acid; In methanol; chloroform; acetic acid; benzene;
DOI:10.1248/cpb.40.1799

Reference yield:

: 145220-97-9
2-Acetoxymethyl-6-formyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-isopropyl ester 5-methyl ester

: 145220-87-7
isopropyl 2-cyano-6-hydroxymethyl-3-methoxycarbonyl-4-(3-nitrophenyl)pyridine-5-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: NH₂OH*HCl, NaOAc / acetic acid / 0.75 h / Ambient temperature

2: Ac₂O / acetic acid / 1.) RT, 1 h, 2.) 100-105 deg C, 3 h, 3.) 115-120 deg C, 4.5 h

3: 95.4 percent / concd aq. NH₃ / methanol; CHCl₃ / 3 h

4: 39.3 percent / aq. HNO₃, AcOH / 1.5 h / Ambient temperature

With ammonium hydroxide; hydroxylamine hydrochloride; nitric acid; sodium acetate; acetic anhydride; acetic acid; In methanol; chloroform; acetic acid;
DOI:10.1248/cpb.40.1799