1-[6-(4-trifluoromethyl-benzylamino)-pyridin-3-yl]-1-(1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-ethanol

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Chemical Name:1-[6-(4-trifluoromethyl-benzylamino)-pyridin-3-yl]-1-(1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-ethanol
CAS No.:1029052-88-7
Molecular Formula:C₃₆H₄₇F₃N₄O₃Si
Molecular Weight:668.875
Hs Code.:

Synonyms:1-[6-(4-trifluoromethyl-benzylamino)-pyridin-3-yl]-1-(1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-ethanol

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Chemical Property of 1-[6-(4-trifluoromethyl-benzylamino)-pyridin-3-yl]-1-(1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-ethanol

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Technology Process of 1-[6-(4-trifluoromethyl-benzylamino)-pyridin-3-yl]-1-(1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-ethanol

There total 3 articles about 1-[6-(4-trifluoromethyl-benzylamino)-pyridin-3-yl]-1-(1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 913983-25-2
3-iodo-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine

: 1029052-87-6
(5-acetyl-pyridin-2-yl)-(4-trifluoromethyl-benzyl)-carbamic acid tert-butyl ester

: 1029052-88-7
1-[6-(4-trifluoromethyl-benzylamino)-pyridin-3-yl]-1-(1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-ethanol

Guidance literature:: 3-iodo-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine; With isopropylmagnesium chloride; In tetrahydrofuran; at -20 ℃; for 1h;

(5-acetyl-pyridin-2-yl)-(4-trifluoromethyl-benzyl)-carbamic acid tert-butyl ester; In tetrahydrofuran; at 20 ℃;

With water; sodium hydrogencarbonate; In ethyl acetate;

Reference yield:

: 923562-49-6
(5-bromo-pyridin-2-yl)-(4-trifluoromethyl-benzyl)-amine

: 1029052-88-7
1-[6-(4-trifluoromethyl-benzylamino)-pyridin-3-yl]-1-(1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-ethanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C

1.2: -78 - 20 °C

2.1: dmap; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 72 h / 20 °C

3.1: isopropylmagnesium chloride / tetrahydrofuran / 1 h / -20 °C

3.2: 20 °C

With dmap; n-butyllithium; isopropylmagnesium chloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; hexane;

Reference yield:

: 1029052-86-5
1-[6-(4-trifluoromethyl-benzylamino)-pyridin-3-yl]-ethanone

: 24424-99-5
di-tert-butyl dicarbonate

: 1029052-88-7
1-[6-(4-trifluoromethyl-benzylamino)-pyridin-3-yl]-1-(1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-ethanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: dmap; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 72 h / 20 °C

2.1: isopropylmagnesium chloride / tetrahydrofuran / 1 h / -20 °C

2.2: 20 °C

With dmap; isopropylmagnesium chloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;