3-amino-N-(3-(((((3-fluorophenyl)amino)carbonyl)amino)methyl)phenyl)-1,2-benzisoxazole-4-carboxamide

Base Information

Chemical Name:3-amino-N-(3-(((((3-fluorophenyl)amino)carbonyl)amino)methyl)phenyl)-1,2-benzisoxazole-4-carboxamide
CAS No.:1104502-47-7
Molecular Formula:C₂₂H₁₈FN₅O₃
Molecular Weight:419.415
Hs Code.:

Synonyms:3-amino-N-(3-(((((3-fluorophenyl)amino)carbonyl)amino)methyl)phenyl)-1,2-benzisoxazole-4-carboxamide

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Chemical Property of 3-amino-N-(3-(((((3-fluorophenyl)amino)carbonyl)amino)methyl)phenyl)-1,2-benzisoxazole-4-carboxamide

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Technology Process of 3-amino-N-(3-(((((3-fluorophenyl)amino)carbonyl)amino)methyl)phenyl)-1,2-benzisoxazole-4-carboxamide

There total 3 articles about 3-amino-N-(3-(((((3-fluorophenyl)amino)carbonyl)amino)methyl)phenyl)-1,2-benzisoxazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1104505-81-8
C₈H₆N₂O₃

: 1104505-83-0
C₁₄H₁₄FN₃O

: 1104502-47-7
3-amino-N-(3-(((((3-fluorophenyl)amino)carbonyl)amino)methyl)phenyl)-1,2-benzisoxazole-4-carboxamide

Guidance literature:: With triethylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

Reference yield:

: C₉H₈N₂O₃

: 1104502-47-7
3-amino-N-(3-(((((3-fluorophenyl)amino)carbonyl)amino)methyl)phenyl)-1,2-benzisoxazole-4-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide / tetrahydrofuran; methanol

2: triethylamine; HATU / N,N-dimethyl-formamide

With triethylamine; HATU; lithium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.05.125

Reference yield:

: 1012367-55-3
4-iodo-benzo[d]isoxazol-3-ylamine

: 1104502-47-7
3-amino-N-(3-(((((3-fluorophenyl)amino)carbonyl)amino)methyl)phenyl)-1,2-benzisoxazole-4-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; triethylamine

2: lithium hydroxide / tetrahydrofuran; methanol

3: triethylamine; HATU / N,N-dimethyl-formamide

With palladium bis[bis(diphenylphosphino)ferrocene] dichloride; triethylamine; HATU; lithium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.05.125