2-Chloro-4-(thiophen-2-yl)pyrimidine

Base Information

Chemical Name:2-Chloro-4-(thiophen-2-yl)pyrimidine
CAS No.:83726-75-4
Molecular Formula:C8H5 Cl N2 S
Molecular Weight:196.66
Hs Code.:2934999090
European Community (EC) Number:871-564-0
DSSTox Substance ID:DTXSID40556152
Nikkaji Number:J340.422F
Wikidata:Q82437634

Synonyms:2-chloro-4-(thiophen-2-yl)pyrimidine;83726-75-4;2-chloro-4-thien-2-ylpyrimidine;2-CHLORO-4-THIOPHEN-2-YLPYRIMIDINE;Pyrimidine, 2-chloro-4-(2-thienyl)-;2-Chloro-4-thiophen-2-yl-pyrimidine;SCHEMBL1536347;DTXSID40556152;2-Chloro-4-(3-thienyl)pyrimidine;2-chloro-4-(thien-2-yl)pyrimidine;MFCD08690327;AKOS006283250;SB55877;AS-62540;CS-0225352;EN300-1234999;Z1198180928

Suppliers and Price of 2-Chloro-4-(thiophen-2-yl)pyrimidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-Chloro-4-(thiophen-2-yl)pyrimidine
100mg
$ 240.00

TRC
2-Chloro-4-(thiophen-2-yl)pyrimidine
10mg
$ 45.00

Chemenu
2-chloro-4-(thiophen-2-yl)pyrimidine 95%
1g
$ 408.00

American Custom Chemicals Corporation
2-CHLORO-4-THIEN-2-YLPYRIMIDINE 95.00%
1G
$ 921.69

American Custom Chemicals Corporation
2-CHLORO-4-THIEN-2-YLPYRIMIDINE 95.00%
250MG
$ 682.78

Total 6 raw suppliers

Chemical Property of 2-Chloro-4-(thiophen-2-yl)pyrimidine

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Refractive Index:1.623
Boiling Point:370.78°C at 760 mmHg
Flash Point:178.042°C
PSA：54.02000
Density:1.379g/cm³
LogP:2.85850
Storage Temp.:2-8°C
XLogP3:2.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:195.9861970
Heavy Atom Count:12
Complexity:156

Purity/Quality:

98%min ^*data from raw suppliers

2-Chloro-4-(thiophen-2-yl)pyrimidine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CSC(=C1)C2=NC(=NC=C2)Cl

Technology Process of 2-Chloro-4-(thiophen-2-yl)pyrimidine

There total 7 articles about 2-Chloro-4-(thiophen-2-yl)pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 188290-36-0,8014-23-1,25233-34-5
thiophene

: 1722-12-9,1195939-87-7
2-chloropyrimidine

: 83726-75-4
2-chloro-4-(thien-2'-yl)pyrimidine

Guidance literature:: thiophene; With n-butyllithium; In diethyl ether; at -40 ℃; for 0.5h;

2-chloropyrimidine; In diethyl ether; at -40 ℃; for 1h;

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; at 20 ℃; for 0.416667h; Further stages.;
DOI:10.1021/jm701182y

Reference yield: 89.0%

: 3934-20-1
2,6-Dichloropyrimidine

: 6165-68-0
thiophene boronic acid

: 83726-75-4
2-chloro-4-(thien-2'-yl)pyrimidine

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In tetrahydrofuran; water; at 90 ℃;

Reference yield: 56.0%

: 188290-36-0,8014-23-1,25233-34-5
thiophene

: 3934-20-1
2,6-Dichloropyrimidine

: 83726-75-4
2-chloro-4-(thien-2'-yl)pyrimidine

Guidance literature:: thiophene; With n-butyllithium; In tetrahydrofuran; at -15 ℃; for 1h; Inert atmosphere;

With zinc dichloro(N,N,N′,N′-tetramethylethylenediamine); In tetrahydrofuran; at -15 - 20 ℃;

2,6-Dichloropyrimidine; regioselective reaction; Further stages;
DOI:10.1055/s-0028-1087347